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Yanti, Kadek Rahayu Darma
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Recent advances and applications in the antibacterial activity of Piper betle leaf extract Wardani, Luh; Ompusunggu, Gabrios Bonauli; Wirawati, Kadek Tania; Yanti, Kadek Rahayu Darma
Pharmacy Reports Vol. 4 No. 1 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.87

Abstract

Piper betle leaves contain diverse phytochemicals including phenolics, alkaloids, and flavonoids that demonstrate significant inhibitory effects against both Gram-positive and Gram-negative bacteria, particularly Staphylococcus aureus and Escherichia coli. The review analyzes extraction methodologies, mechanistic aspects of antimicrobial action, and efficacy against specific pathogens. Applications across multiple domains are explored, including clinical treatments for ocular and dental infections, advanced wound healing systems, food preservation through biodegradable packaging, and functional materials development. Despite promising results, challenges remain in standardization, active compound identification, and delivery system optimization. By synthesizing research from the past five years, this review provides a foundation for future development of P. betle-based antimicrobial applications that may help address the global challenge of antimicrobial resistance.
The pharmacological potential of sappan wood (Caesalpinia sappan L.): A review of recent evidence Wirawati, Kadek Tania; Ompusunggu, Gabrios Bonauli; Wardani, Luh; Yanti, Kadek Rahayu Darma
Pharmacy Reports Vol. 3 No. 3 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.86

Abstract

Sappan wood (Caesalpinia sappan L.) has been used in traditional Asian medicine for centuries, but its pharmacological properties have only recently been systematically investigated using modern scientific methods. This review aims to synthesize current research on the pharmacological activities of sappan wood and assess its potential for development into evidence-based therapeutic applications. A systematic literature search following PRISMA 2020 guidelines was conducted in ScienceDirect and PubMed databases using specific keywords. Articles published between 2014-2024 investigating the pharmacological properties of sappan wood were included, yielding nine studies for qualitative analysis. Evidence demonstrates that sappan wood possesses significant anti-inflammatory, antibacterial, antioxidant, wound healing, antidiabetic, and anti-HIV properties. Brazilin emerges as a key bioactive compound, though synergistic effects among multiple constituents enhance certain activities. Multiple mechanisms of action were identified, including inhibition of pro-inflammatory cytokines, antibacterial effects against both Gram-positive and Gram-negative bacteria, and activation of antioxidant pathways. Sappan wood shows promising potential as a source of natural pharmacological agents with diverse therapeutic applications. Future research should focus on clinical validation, standardization of extracts, and elucidation of molecular mechanisms to facilitate its integration into modern healthcare.
Co-Authors Ompusunggu, Gabrios Bonauli Wardani, Luh Wirawati, Kadek Tania