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Banana-derived excipients: drug release, performance, and stability Fauzi, Muh Fajar
Pharmacy Reports Vol. 5 No. 1 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.99

Abstract

Banana-derived excipients have garnered increasing attention due to their potential as natural, sustainable alternatives in pharmaceutical formulations. This study systematically reviewed the effectiveness and compatibility of banana-based excipients compared to conventional synthetic and natural counterparts. A comprehensive literature review was conducted following the PICOS framework, covering studies published between 2013 and 2024. Data extraction focused on physicochemical characterization, functional performance, and drug release properties of banana-derived excipients across various dosage forms. The results indicate that banana starch and crude banana powder exhibit promising binding, disintegrant, and mucoadhesive properties. Their performance in pharmaceutical formulations was comparable to widely used excipients such as maize starch, polyvinylpyrrolidone (PVP), and microcrystalline cellulose. Notably, banana-derived excipients demonstrated sustained-release effects and potential bioavailability enhancement. However, a lack of standardization in processing methods and limited stability data highlight the need for further research to ensure reproducibility and regulatory compliance. Despite their advantages, challenges remain in optimizing formulations and understanding long-term interactions with drug compounds. Future studies should focus on in vivo validation and stability assessments to enhance the adoption of banana-based excipients in pharmaceutical applications. This research contributes to the growing field of sustainable pharmaceutical development by advocating for the integration of environmentally friendly excipients into modern drug formulations.
Standardization of Paku Lindung extract (Pneumatopteris callosa (Blume)) Fauzi, Muh Fajar; Widyaningsih, Wahyu
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.23941

Abstract

The standardization of the paku lindung extract was carried out to obtain new data regarding the standardization of the hedgehog extract which had not previously been established. In addition, this determination is carried out to obtain quality preparations in the form of a guarantee process, that the extract obtained has certain parameter values that are constant after the data has been determined. Extract standardization test includes specific parameters including organoleptic, soluble compounds in certain solvents. Non-specific parameter tests include drying shrinkage, moisture content, ash content, heavy metal contamination, microbial contamination. Chemical content test includes chromatogram pattern, determination of total flavonoid content. The yield of the resulting extract was 13.88±3.19% g. The test results of non-specific parameters include drying shrinkage 0.47±0.01%, moisture content 8.28±0.16%, total ash content 18.97±3.53%, acid insoluble ash content 1.69± 0.02%, total plate number 7.8x104±12.91 colonies/gram, yeast mold number 1x102±0.24 colonies/gram, heavy metal contamination of Cd, Cr and Pb negative and Fe of 73.88 ppm. The results of the specific parameter test include 85.55±4.29% water soluble compounds, 31.27±5.06% ethanol soluble compounds. The results of the chemical content test included the total flavonoid content of 16.6±17.60 mgEQ/g, the Rf value of the extract was the same as the Rf of quercetin with 5 variations of the mobile phase. The test results were carried out to meet the predetermined determination and provide new data on the standardization of the paku lindung extract.