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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Mejuajua PAKDEMAS : Jurnal Pengabdian Kepada Masyarakat Pharmacy Reports
Muh. Fajar Fauzi
Department Of Pharmacy, Faculty Of Science, Institut Teknologi Sumatera, South Lampung 35365, Indonesia
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Banana-derived excipients: drug release, performance, and stability Fauzi, Muh Fajar
Pharmacy Reports Vol. 5 No. 1 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.99

Abstract

Banana-derived excipients have garnered increasing attention due to their potential as natural, sustainable alternatives in pharmaceutical formulations. This study systematically reviewed the effectiveness and compatibility of banana-based excipients compared to conventional synthetic and natural counterparts. A comprehensive literature review was conducted following the PICOS framework, covering studies published between 2013 and 2024. Data extraction focused on physicochemical characterization, functional performance, and drug release properties of banana-derived excipients across various dosage forms. The results indicate that banana starch and crude banana powder exhibit promising binding, disintegrant, and mucoadhesive properties. Their performance in pharmaceutical formulations was comparable to widely used excipients such as maize starch, polyvinylpyrrolidone (PVP), and microcrystalline cellulose. Notably, banana-derived excipients demonstrated sustained-release effects and potential bioavailability enhancement. However, a lack of standardization in processing methods and limited stability data highlight the need for further research to ensure reproducibility and regulatory compliance. Despite their advantages, challenges remain in optimizing formulations and understanding long-term interactions with drug compounds. Future studies should focus on in vivo validation and stability assessments to enhance the adoption of banana-based excipients in pharmaceutical applications. This research contributes to the growing field of sustainable pharmaceutical development by advocating for the integration of environmentally friendly excipients into modern drug formulations.
Edukasi dan Pelatihan Pembuatan Minuman Fungsional Anti Anemia di SMA 2 Muhammadiyah Bandar Lampung Nurnahari, Naura; Aziz, Syaikhul; Fauziyya, Riri; Nur Auli, Winni; Maulidia Rahayyu, Annisa; Kartika Sari Ramadhani, Untia; Azanti Putri, Refsya; Fajar Fauzi, Muh; Sekarsari Yusuf, Mubarika; Mulyani, Isna
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 5 No. 1 (2025): Agustus 2025
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v5i1.236

Abstract

Anemia adalah suatu kondisi di mana jumlah sel darah merah atau konsentrasi Hemoglobin di dalam darah lebih rendah dari normal. Berdasarkan Survei Kesehatan Nasional Indonesia 2023, prevalensi anemia pada kelompok  usia 15-24 tahun sebesar 15,5%. Anemia bisa dicegah dengan nutrisi yang tepat. Tujuan pengabdian masyarakat ini adalah mengedukasi para remaja mengenai pemanfaatan bahan alam untuk mencegah anemia serta pelatihan pembuatan minuman fungsional untuk mencegah anemia. Kegiatan ini berlangsung di SMA 2 Muhammadiyah Bandar Lampung dan melibatkan 39 siswa-siswi. Metode yang diterapkan dalam kegiatan ini meliputi ceramah dan demonstrasi. Penilaian peningkatan pengetahuan dilakukan melalui pre-test dan post-test. Evaluasi dilakukan menggunakan instrumen pre-test dan post-test yang terdiri dari 10 butir pertanyaan. Uji normalitas Shapiro-Wilk menunjukkan bahwa data berdistribusi normal (pre-test p = 0,7485; post-test p = 0,2501), sehingga dilanjutkan dengan uji paired sample t-test. Hasil analisis menunjukkan peningkatan yang signifikan secara statistik (p = 0,0008), dengan rata-rata skor meningkat dari 59,3% menjadi 80,5%.
Standardization of Paku Lindung extract (Pneumatopteris callosa (Blume)) Fauzi, Muh Fajar; Widyaningsih, Wahyu
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.23941

Abstract

The standardization of the paku lindung extract was carried out to obtain new data regarding the standardization of the hedgehog extract which had not previously been established. In addition, this determination is carried out to obtain quality preparations in the form of a guarantee process, that the extract obtained has certain parameter values that are constant after the data has been determined. Extract standardization test includes specific parameters including organoleptic, soluble compounds in certain solvents. Non-specific parameter tests include drying shrinkage, moisture content, ash content, heavy metal contamination, microbial contamination. Chemical content test includes chromatogram pattern, determination of total flavonoid content. The yield of the resulting extract was 13.88±3.19% g. The test results of non-specific parameters include drying shrinkage 0.47±0.01%, moisture content 8.28±0.16%, total ash content 18.97±3.53%, acid insoluble ash content 1.69± 0.02%, total plate number 7.8x104±12.91 colonies/gram, yeast mold number 1x102±0.24 colonies/gram, heavy metal contamination of Cd, Cr and Pb negative and Fe of 73.88 ppm. The results of the specific parameter test include 85.55±4.29% water soluble compounds, 31.27±5.06% ethanol soluble compounds. The results of the chemical content test included the total flavonoid content of 16.6±17.60 mgEQ/g, the Rf value of the extract was the same as the Rf of quercetin with 5 variations of the mobile phase. The test results were carried out to meet the predetermined determination and provide new data on the standardization of the paku lindung extract.
Stability and efficacy of green solvent and natural excipient-based semisolid formulations compared with conventional formulations: a review Muh Fajar Fauzi; Eko Hidayaturrohman Khumaini
Pharmacy Reports Vol. 5 No. 3 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.118

Abstract

Semisolid dosage forms, including creams, gels, ointments, hydrogels, and emulgels, are widely used for topical drug delivery. Green solvent- and natural excipient-based systems have gained attention for their potential biocompatibility and reduced environmental burden, but their stability advantages over conventional formulations remain unclear. This systematic review with narrative synthesis evaluated 36 eligible studies from 1,000 records. Due to the methodological and clinical heterogeneity of the included studies, a narrative synthesis was conducted in place of quantitative pooling. Among 20 studies reporting direct comparative efficacy, 11 showed superior results for green or natural formulations, 7 reported equivalence, and 2 had mixed findings. Safety outcomes were generally comparable or more favorable for green formulations, with no serious adverse events linked to these systems. However, stability evidence was limited: only 9 studies reported stability-related parameters, and long-term or accelerated data were largely absent. While green solvent- and natural excipient-based semisolid formulations demonstrate promising efficacy and tolerability, current evidence does not establish that they are inherently more stable than conventional systems, and their translational readiness remains constrained by insufficient demonstration of reproducible formulation quality over time.
Optimizing a vaseline–lanolin ointment base for Momordica charantia extract using a simplex lattice design Muh Fajar Fauzi; Sarmoko; Tantri Liris Nareswari; Ahmad Bayu Satriawan; Nisa Yulianti Suprahman; Evi Kurniawaty
Pharmacy Reports Vol. 6 No. 1 (2026): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.126

Abstract

Topical delivery of Momordica charantia (bitter melon) extract is a promising approach for anti-inflammatory and antioxidant therapy, yet the performance of the dosage form depends strongly on the composition of the formulation base. This study aimed to optimize a two-component vaseline–lanolin ointment base for M. charantia extract using a simplex lattice mixture design. Five blends spanning the binary mixture space were prepared and characterized for viscosity, spreadability, adhesiveness, and pH. Polynomial mixture models were fitted to each response, model adequacy was assessed by analysis of variance and lack-of-fit testing, and a multi-response Derringer desirability function was applied to locate a compromise optimum, which was then verified experimentally. Increasing the lanolin proportion generally increased viscosity and adhesiveness but reduced spreadability, whereas higher vaseline fractions improved spreadability while maintaining pH within a skin-compatible range. The models showed good fit and predictive utility, and the selected blend (vaseline:lanolin = 70:30) met all predefined physical criteria, with observed responses showing no significant difference from predicted values. In conclusion, simplex lattice optimization efficiently guided the vaseline–lanolin ratio toward a base with favorable rheological properties, providing a useful and reproducible platform for incorporating M. charantia extract in future efficacy and stability studies.
Network pharmacology and molecular docking of cucurbitane-type triterpenoids from Momordica charantia against psoriasis-associated targets Ahmad Bayu Satriawan; Sarmoko; Tantri Liris Nareswari; Nisa Yulianti Suprahman; Muh Fajar Fauzi; I Gede Raditya Purwanata
Pharmacy Reports Vol. 6 No. 3 (2026): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.127

Abstract

Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by keratinocyte hyperproliferation, persistent inflammation, dysregulated apoptosis, and tissue remodeling. Momordica charantia has attracted attention as a potential anti-psoriatic herbal candidate; however, the molecular basis of its bioactive metabolites remains insufficiently understood. This study investigated the anti-psoriatic potential of cucurbitane-type triterpenoids from M. charantia using integrated network pharmacology and molecular docking. Of 192 secondary metabolites, 50 passed pharmacokinetic and toxicity screening, yielding 347 predicted human targets, of which 159 overlapped with 3,383 psoriasis-associated genes. Key hub genes identified by protein-protein interaction and topological analyses included AKT1, TNF, EGFR, STAT3, IL1B, CASP3, MMP9, HIF1A, and ESR1, with enriched biological processes related to oxidative stress, lipid and hormonal responses, and intracellular receptor signaling. Molecular docking of five cucurbitane-type triterpenoids against four validated hub proteins demonstrated consistently favorable predicted binding affinities for AKT1 via its allosteric pocket, as well as for EGFR and IL1B. Karavilagenin A showed the most favorable binding energy against AKT1, momordicin I against EGFR and IL1B, and cucurbitacin B demonstrated favorable profiles across multiple targets. These findings suggest that M. charantia may influence psoriasis-related biology through multi-target mechanisms, providing a basis for further experimental validation.
Pemberdayaan Sekolah Berwawasan Lingkungan melalui Edukasi Kosmetika Alami dan Penanaman Tanaman Obat di SMA Negeri 1 Pagar Dewa Isna Mulyani; Gayatri Simanullang; Naura Nurnahari; Muh. Fajar Fauzi; Reny Haryani
PAKDEMAS : Jurnal Pengabdian Kepada Masyarakat Vol 5 No 1 (2025): Desember
Publisher : Fakultas Pertanian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/pakdemas.v5i1.568

Abstract

Kegiatan pengabdian kepada masyarakat berjudul “Pemberdayaan Sekolah Berwawasan Lingkungan melalui Edukasi Kosmetika Alami dan Penanaman Tanaman Obat di SMA Negeri 1 Pagar Dewa” telah terlaksana melalui tiga tahap. Tahap awal meliputi koordinasi dengan pihak sekolah dan survei lokasi penanaman. Tahap kedua, pelaksanaan edukasi mengenai kosmetika aman untuk remaja dan workshop pemanfaatan bahan alam sebagai dasar pembuatan kosmetika alami. Tahap ketiga adalah penanaman tumbuhan obat yang berpotensi digunakan sebagai bahan kosmetika. Edukasi diberikan melalui sesi penyuluhan interaktif yang diikuti oleh guru dan siswa, dengan materi seputar bahaya bahan kimia, cara membaca label kemasan, pemilihan kosmetik sesuai jenis kulit dan usia dan potensi tanaman obat lokal produk kosmetik ramah lingkungan. Selain itu, peserta juga difasilitasi praktik sederhana pembuatan produk berbasis bahan alam, seperti masker dan facial wash, sehingga siswa memperoleh keterampilan aplikatif yang dapat langsung diterapkan. Pada tahap berikutnya, kegiatan akan difokuskan pada penanaman dua puluh delapan jenis tanaman obat di lingkungan sekolah, di antaranya lidah buaya, kunyit, jahe, dan bunga telang. Penanaman ini diharapkan tidak hanya menjadi sarana edukasi berkelanjutan, tetapi juga memperkuat konsep sekolah berwawasan lingkungan. Setelah itu, tim akan melakukan pendampingan dalam pengelolaan kebun tanaman obat. Dengan demikian, program pengabdian ini tidak hanya meningkatkan pengetahuan, tetapi juga membangun kemandirian dan menumbuhkan kepedulian siswa terhadap pemanfaatan sumber daya alam secara berkelanjutan.
Co-Authors Eko Hidayaturrohman Khumaini Evi Kurniawaty Fauziyya, Riri Gayatri Simanullang I Gede Raditya Purwanata Isna Mulyani Kartika Sari Ramadhani, Untia Nisa Yulianti Suprahman Nisa Yulianti Suprahman Nurnahari, Naura Rahayyu, Annisa Maulidia Refsya Azanti Putri Reny Haryani Sarmoko Sarmoko Satriawan, Ahmad Bayu Sekarsari Yusuf, Mubarika Syaikhul Aziz Tantri Liris Nareswari Wahyu Widyaningsih Winni Nur Auli