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All Journal Action Research Literate (ARL) Jurnal Indonesia Sosial Sains
Fayyadh, Achmad
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Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Energy Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Neuroscience Physics Social Sciences

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Analisis Ekstrak Kulit Nanas (Ananas Comosus L.) Sebagai Antibakteri Streptoccocus Mutans Secara In Silico Fayyadh, Achmad
Action Research Literate Vol. 9 No. 3 (2025): Action Research Literate
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/arl.v9i3.2851

Abstract

Kasus karies gigi menjadi permasalahan yang terus meningkat pada pasien dewasa dan anak-anak yang salah satu penyebabnya adalah bakteri Streptococcus mutans. Kulit nanas (Ananas comosus L) merupakan bagian tanaman yang telah diketahui memiliki aktivitas sebagai antibakteri karena adanya kandungan metabolit sekunder epicatechin dan quercetin.  Akan tetapi, eksplorasi kulit nanas sebagai antibakteri belum banyak dilakukan. Penelitian ini bertujuan untuk mengekstraksi kulit nanas, melakukan analisis profil fitokimia ekstrak, dan  menguji aktivitas antibakteri ekstrak kulit nanas pada Streptococcus mutans melalui molecular docking pada target protein karies gigi. Metode ekstraksi dilakukan dengan maserasi pelarut etanol 70% kemudian hasil ekstrak dilakukan pengujian skrining fitokimia secara kualitatif. Pengujian aktivitas antibakteri secara In Silico dilakukan dengan molecular docking pada protein Ag I/II dan GbpC. Hasil maserasi didapatkan rendemen ekstrak kulit nanas 6,88%. Ekstrak secara kualitatif positif mengandung alkaloid, saponin, flavonoid, kuinon, polifenol, dan triterpenoid. Hasil pengujian antibakteri secara in silico menunjukkan epicatechin sebagai penghambat protein Ag I/II dan quercetin sebagai penghambat protein GbpC terbaik.
PIENNO-MOASH: Formulation of Nanoparticle Mouthwash from Pineapple Peel Extract (Ananas comosus L.) as an Antibacterial Agent Against Streptococcus mutans via In Silico and In Vitro Studies Fayyadh, Achmad; Ferya, Fachri; Fitriana, Aiza
Jurnal Indonesia Sosial Sains Vol. 6 No. 3 (2025): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v6i3.1668

Abstract

Dental caries cases are an increasing problem in adult and pediatric patients, one of the causes of which is the Streptococcus mutans bacteria. Pineapple peel (Ananas comosus L.) is a plant part that has been known to have antibacterial activity due to the content of secondary metabolites epicatechin and quercetin. However, the exploration of pineapple peel as a nanoparticle mouthwash has not been widely done. This study aims to extract pineapple peel, analyze the phytochemical profile of the extract, conduct molecular docking tests on dental caries protein targets, test the antibacterial activity of pineapple peel extract on Streptococcus mutans cultures, optimize and evaluate the formulation of "PIENNO-MOASH" nanoparticle mouthwash preparations. The extraction method was carried out by maceration of 70% ethanol solvent then the extract results were qualitatively tested for phytochemical screening. In silico antibacterial activity testing was carried out by molecular docking on Ag I/II and GbpC proteins. While testing antibacterial activity in vitro using disc diffusion method with pineapple peel extract concentration. The results of maceration obtained yield of pineapple peel extract 6.88%. Qualitatively positive extracts contain alkaloids, saponins, flavonoids, quinones, polyphenols, and triterpenoids. In silico antibacterial testing results showed epicatechin as the best Ag I/II protein inhibitor and quercetin as the best GbpC protein inhibitor. The results of antibacterial testing in vitro could not be analyzed due to the appearance of bacterial contamination. The results of optimization and evaluation showed that formulation F2 had particle size, specific gravity, pH, and viscosity that met the nanoparticle preparation. So it can be concluded that pineapple peel extract contains secondary metabolites that can affect the growth of Streptoccocus mutans bacteria and formula F2 has a composition that meets the requirements of nanoparticle mouthwash preparations.
Co-Authors Ferya, Fachri fitriana, aiza