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Laparoscopic Management of Incarcerated Femoral Hernia with Bowel Necrosis: A Case Report Handito Sarwwotatwadhiko; Anung Noto Nugroho
Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 5 (2025): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v5i5.736

Abstract

Femoral hernias, though representing less than 5% of all abdominal wall hernias, pose a significant clinical challenge due to their anatomical constraints and high complication rates. Exhibiting a pronounced female predominance, these hernias carry a substantial risk of incarceration and strangulation, estimated between 5-20%, stemming from the narrow and unyielding nature of the femoral canal. This anatomical predisposition frequently mandates urgent surgical intervention to prevent bowel ischemia and necrosis. Diagnostic difficulties often arise, particularly in occult presentations lacking a discernible groin mass. The advent of laparoscopy has revolutionized the approach, offering distinct advantages in both the diagnosis of clinically obscure hernias and the execution of minimally invasive repair, potentially improving patient outcomes. We present the case of a 63-year-old female who arrived at the emergency department complaining of a three-day duration of severe, intermittent abdominal pain associated with obstipation, progressive abdominal distension, nausea, and vomiting. Clinical examination revealed marked abdominal distension but failed to identify any palpable mass in the inguinal or femoral regions. Plain abdominal radiography indicated findings consistent with small bowel obstruction. Consequently, an exploratory laparoscopy was undertaken. Intraoperatively, an incarcerated right femoral hernia was discovered, containing a 4 cm segment of ileum that exhibited frank necrosis. A completely laparoscopic procedure involving small bowel resection, creation of a side-to-side ileoileal anastomosis, and subsequent repair of the femoral hernia defect using primary purse-string sutures was performed successfully. In conclusion, the laparoscopic approach was indispensable for the accurate diagnosis and effective management of this complex case involving an occult, incarcerated femoral hernia with resultant bowel necrosis. Employing a minimally invasive strategy facilitated simultaneous bowel resection and hernia repair, offering potential benefits including diminished postoperative discomfort, expedited recovery, and possibly lower long-term recurrence rates relative to traditional open surgical techniques. This case reinforces the critical importance of considering femoral hernia in the differential diagnosis of female patients presenting with acute small bowel obstruction, even in the absence of classical external signs. Furthermore, it underscores the feasibility and efficacy of a purely laparoscopic approach for managing such complex surgical emergencies.
Evaluating Progesterone Level Fluctuations as a Response Indicator to Chemotherapy in Triple Negative Breast Cancer Handito Sarwwotatwadhiko; Widyanti Soewoto; Ida Bagus Budhi Surya
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1334

Abstract

Background: Triple negative breast cancer (TNBC) represents an aggressive subtype with limited targeted therapies and often poorer prognosis. Chemotherapy remains a cornerstone of treatment, yet its systemic effects, including hormonal alterations, are not fully elucidated. The role of progesterone in TNBC progression and its modulation by chemotherapy is particularly complex and warrants investigation. This study aimed to evaluate changes in serum progesterone levels following chemotherapy in TNBC patients. Methods: A prospective cohort study was conducted at Dr. Moewardi General Hospital, Surakarta, involving 30 patients diagnosed with TNBC undergoing chemotherapy. Serum progesterone levels were quantified using the ELISA method before the first chemotherapy cycle and after the sixth cycle. Statistical analysis, primarily the Wilcoxon test, was used to compare pre- and post-chemotherapy levels. Results: The cohort had a mean age of 49.13 ± 8.98 years. Prior to chemotherapy, progesterone levels varied: 53.3% were below normal (<0.5 ng/mL), 23.3% were normal (0.5-5 ng/mL), and 23.3% were above normal (>5 ng/mL). Following six cycles of chemotherapy, a significant decrease in progesterone levels was observed (p=0.020). The proportion of patients with below-normal levels increased to 63.3%. Overall, 10 patients showed decreased levels, 18 remained stable, and 2 showed increased levels. No significant correlation was found between progesterone level changes and baseline patient characteristics like age, menarche, or menopausal status. Conclusion: Systemic chemotherapy significantly impacts progesterone levels in TNBC patients, leading to an overall decrease. Monitoring progesterone fluctuations during treatment may hold potential value for assessing therapeutic response or prognosis, warranting further investigation.
Evaluating Progesterone Level Fluctuations as a Response Indicator to Chemotherapy in Triple Negative Breast Cancer Handito Sarwwotatwadhiko; Widyanti Soewoto; Ida Bagus Budhi Surya
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1334

Abstract

Background: Triple negative breast cancer (TNBC) represents an aggressive subtype with limited targeted therapies and often poorer prognosis. Chemotherapy remains a cornerstone of treatment, yet its systemic effects, including hormonal alterations, are not fully elucidated. The role of progesterone in TNBC progression and its modulation by chemotherapy is particularly complex and warrants investigation. This study aimed to evaluate changes in serum progesterone levels following chemotherapy in TNBC patients. Methods: A prospective cohort study was conducted at Dr. Moewardi General Hospital, Surakarta, involving 30 patients diagnosed with TNBC undergoing chemotherapy. Serum progesterone levels were quantified using the ELISA method before the first chemotherapy cycle and after the sixth cycle. Statistical analysis, primarily the Wilcoxon test, was used to compare pre- and post-chemotherapy levels. Results: The cohort had a mean age of 49.13 ± 8.98 years. Prior to chemotherapy, progesterone levels varied: 53.3% were below normal (<0.5 ng/mL), 23.3% were normal (0.5-5 ng/mL), and 23.3% were above normal (>5 ng/mL). Following six cycles of chemotherapy, a significant decrease in progesterone levels was observed (p=0.020). The proportion of patients with below-normal levels increased to 63.3%. Overall, 10 patients showed decreased levels, 18 remained stable, and 2 showed increased levels. No significant correlation was found between progesterone level changes and baseline patient characteristics like age, menarche, or menopausal status. Conclusion: Systemic chemotherapy significantly impacts progesterone levels in TNBC patients, leading to an overall decrease. Monitoring progesterone fluctuations during treatment may hold potential value for assessing therapeutic response or prognosis, warranting further investigation.