Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmako Bahari Jurnal Farmasi Indonesia
Handayanti, Isnani
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Cytotoxic Activity Test Of Ethanolic Extract Of Berenuk Fruit (Crescentia Cujete L.) On Artemia Salina Leach Shrimp Larva Using Brine Shrimp Lethality Test (BSLT) Method Suzana, Dona; Handayanti, Isnani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.722 KB) | DOI: 10.35617/jfionline.v14i1.109

Abstract

Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy, which has cytotoxic effects. One of the plants that has the same effect is berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae. This plant contains napthoquinone as one of its cytotoxic chemical compounds and other secondary metabolites such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. The objective of this study is to determine the cytotoxic activity of an ethanolic extract of the fruit of berenuk on Artemia salina Leach larvae. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larvae that had been prepared and the value of mortality was observed. The result of a cytotoxic activity test of an ethanolic extract of berenuk fruit on A. salina larvae had a LC50 value of 529.386 ppm, which is categorized as toxic.
Evaluation of Antiacne Patch Preparations from a Combination of Lemon Juice (Citrus limon L.) and Ethanol Extract of Pure Honey (Honey bee) Tsurayya, Nadya; Choir, Ubaydullah; Kurniawan, Agus; Handayanti, Isnani
Jurnal Ilmiah Farmako Bahari Vol 17 No 1 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i1.43071

Abstract

Acne vulgaris is one of the most common dermatological diseases, affecting individuals of all ages, particularly during adolescence. One of the causes of acne vulgaris is the bacterium Cutibacterium acnes. Acne vulgaris is usually characterized by comedones, papules, pustules, or nodules. Factors influencing acne include genetics, psychological factors, hormones, bacterial infection, and sebaceous gland activity. One regularly used treatment for acne vulgaris is acne patches. With the aid of natural ingredients such as lemon juice and pure honey, an alternative treatment for acne vulgaris can be developed. Lemon juice (Citrus limon L.) can be utilized as an antibacterial agent against Cutibacterium acnes due to its flavonoid content, which has biological activity as an antibacterial. Meanwhile, pure honey (Honey bee) is an antioxidant that can kill bacteria and germs, causing itchy acne on the skin, and can help fade acne scars. The study employed a laboratory experimental design. This research aimed to formulate an anti-acne patch preparation containing a combination of lemon juice (Citrus limon L.) and an ethanol extract of pure honey (Honey bee) that would exhibit good physical stability. Evaluation of the anti-acne patch preparation included organoleptic tests, pH, weight uniformity, patch thickness, moisture absorption, and antibacterial activity tests against Cutibacterium acnes using the disk diffusion method. The results indicated that the anti-acne patch exhibited favorable physical properties. The combination of lemon juice and ethanol extract of pure honey enhanced antibacterial activity against Cutibacterium acnes. The antibacterial activity test results showed that the combination of lemon juice and ethanol extract of pure honey in the anti-acne patch at a concentration of 14% had the highest antibacterial activity, with an inhibition zone diameter of 51.38 mm.
Co-Authors Agus Kurniawan Choir, Ubaydullah Suzana, Dona Tsurayya, Nadya