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All Journal Pharmaciana: Jurnal Kefarmasian
Damayanti, Resty Annisa
Farmasi UAD
Medicine & Pharmacology

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DIMETILSULFOKSID SEBAGAI ENHANCER TRANSPOR TRANSDERMAL TEOFILIN SEDIAAN GEL Damayanti, Resty Annisa; Yuwono, Tedjo
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.142 KB) | DOI: 10.12928/pharmaciana.v3i1.419

Abstract

Dimethylsulfoxide (DMSO) has been intensively studied the 19th century. Thissubstance is used as a medicine and solve. It can also be used as an absorptionenhancer of various drugs, either synthetical or herbal medicines. This study conductedwith DMSO as transdermal absorption enhancer of theophylline, which often used asan anti-cellulite dosage forms. The experiments studied in vitro transdermalabsorption of theophylline in gel dosage forms, containing 7% theophylline danvarious concentration of DMSO i.e. 0% , 3%, 5% and 7% DMSO respectively. Thesestudies used skin membrane of Wistar strain male rats in a vertical type diffusion Cell.The results indicated that DMSO was very potential as a permeation enhancertheophylline, the formula containing 7% DMSO increased the theophylline transportfrom 17,9 µg to 139,1 µg.
Co-Authors Yuwono, Tedjo