<![CDATA[Background: Diagnostic approaches for appendicitis have evolved to improve accuracy and reduce negative appendectomy rates. Laboratory markers and imaging modalities have been developed to provide supportive but non-specific information. However, challenges persist in balancing accuracy with concerns like radiation exposure and cost-effectiveness. This systematic review seeks to synthesize existing evidence on diagnostic approaches in acute appendicitis, examining their performance, limitations, and potential for standardized integration into clinical practice. Methods: This systematic review was conducted in accordance with the PRISMA 2020 guidelines, incorporating only full-text, peer-reviewed articles published in English from 2015 to 2025. To maintain the integrity and reliability of the sources, editorial pieces and review articles lacking a Digital Object Identifier (DOI) were excluded. A comprehensive literature search was performed using databases such as ScienceDirect, PubMed, and SAGE Publications to identify relevant studies. Result: An initial search of selected databases identified over 300 potentially relevant studies. After a structured three-phase screening process, only eight met the inclusion criteria for detailed review. These articles underwent rigorous critical appraisal to evaluate their relevance and quality. This ensured that the final analysis was based on strong evidence aligned with the study’s objectives. Conclusion: The effective diagnosis and management of acute appendicitis necessitate an integrated approach involving clinical scoring systems, imaging studies, and evidence-based surgical decision-making. Imaging is crucial for confirmation and planning, while timely surgical intervention is essential. Advancements in diagnostic tools and surgical techniques can improve patient outcomes and reduce healthcare burden.]]>
