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Handayani, Rizqya Cahya
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health

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Enhanced Anti-Inflammatory Activity of Passiflora edulis Leaf Extract Nanoparticle Gel in Carrageenan-Induced Rat Model Sandhiutami, Ni Made Dwi; Desmiaty, Yesi; Fahleni, Fahleni; Handayani, Rizqya Cahya; Ciang, Windy
Sciences of Pharmacy Volume 4 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0401301

Abstract

Passion fruit (Passiflora edulis) leaf extract is rich in flavonoids, which possess anti-inflammatory properties. This study aimed to enhance the anti-inflammatory effect of the extract through a nanoparticle gel formulation. Nanoparticles of the extract (NEP) were prepared using ionic gelation with a Carbomer 940 base. The anti-inflammatory efficacy of NEP was evaluated in vivo using a carrageenan-induced paw edema model in rats. Five groups (n=5) were tested: a negative control (Carbomer 940 gel base), a positive control (Sodium Diclofenac), and three NEP formulations with concentrations of 1% (NEP-1), 3% (NEP-2), and 5% (NEP-3). The NEP gels were homogeneous with a faint yellow color and a characteristic odor. Their spreadability ranged from 7.50 ± 0.67 cm to 7.69 ± 1.26 cm, viscosity exhibited plastic flow properties, and pH values were within 4.47 ± 0.06 to 5.20 ± 0.10. The anti-inflammatory effectiveness of NEP formulations increased with concentration, achieving edema inhibition rates of 3.66% (NEP-1), 68.47% (NEP-2), and 82.37% (NEP-3). In conclusion, the nanoparticle gel formulations of passion fruit leaf extract demonstrated good physical properties, with NEP-3 being the most effective in reducing carrageenan-induced paw edema in rats.
Co-Authors Ciang, Windy Fahleni Fahleni Ni Made Dwi Sandhiutami Yesi Desmiaty, Yesi