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All Journal Pharmaciana: Jurnal Kefarmasian
Zainab, Zainab
Farmasi UAD
Medicine & Pharmacology

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PENGARUH KONSENTRASI ETANOL SEBAGAI PELARUT PENGEKSTRAKSI TERHADAP KADAR NAFTOKINON DALAM EKSTRAK DAUN PACAR KUKU (Lawsonia inermis L.) Zainab, Zainab
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.152 KB) | DOI: 10.12928/pharmaciana.v3i2.433

Abstract

The extract quality can be affected by the components and concentration of chemical compounds containedin the extract.Type and quantities of chemical compounds that are dissolved in the extraction process is stronglyinfluenced by the solvent extraction. The aim of this study is to determine the effect of concentration of ethanol assolvent extraction on naphthoquinone content in Henna leaves extract. The extraction method was done bymaceration for one hours with water, ethanol 50% , 70% , 90% and 95% v/v solvens of the dried Henna leavespowder. Each macerate was made 5 % w/v concentration and than was spotted 5 µL on plate of silica gel F 254 andeluted with mixture of chloroform - methanol (17:3 v/v) as mobile phase. The spots on chromathogram werescanning and measured the area under curve with TLC densitometer at maximum wave lenght. The results showedthat spot at Rf 0.31 had similar spectra with naphthoquinone standard and same maximum wavelength at 279 nm.The result of solvent optimization indicated that the best solvent extraction for Henna leaves was ethanol 50% v/vwith the highest naphthoquinone contentat 1.43 ± 0.1942% w/v.
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETER HASIL HIDROLISIS INFUSA DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DENGAN METODE DPPH (1,1-DIPHENIL-2-PICRYLHYDRAZYL) Ardianti, Agustina; Guntarti, Any; Zainab, Zainab
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (76.223 KB) | DOI: 10.12928/pharmaciana.v4i1.391

Abstract

Antioxidant is compounds which have abilities to inhibit oxidation rate. Anredera cordifoliafolium consist of flavonoid which have activities as antioxidant. The purpose of this research was toknow antioxidant activity at ether fraction of hydrolysed aquous extract of Binahong folium (Anrederacordifolia). Ether fraction was obtained by hydrolysing the infuse Binahong folium (Anrederacordifolia) with HCl 2N then fractionated with ether and then evaporated. The antioxidant activity wasmeasured by DPPH method using spectrophotometer. The maximum wavelength and operating timequercetin and samples were 515,0 nm (quersetin) and 514,0 nm (ether fraction), 19-30 minute(quersetin) and 19-29 minute (ether fraction). Scavenging activity test done with the DPPH method(1,1- dyphenyl-2-picrylhydrazyl). The decreasing of DPPH radical solution decreased the absorbantintensity. The percentage of radical scavenging activity was performed as EC50 (EffectiveConcentration). The results indicated that both samples showed free radical scavenging activity withEC50 value for quercetin (2,702±0,15) µg/ml, and ether fraction of (249,31±9,26) µg/ml. Statisticalanalysis using Kruskall Wallis method with 95% of confident level followed by Mann Whitney testgiving evidence the results between samples and positive control (quercetin) are significantlydifference.
Co-Authors Any Guntarti Ardianti, Agustina