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All Journal Pharmaciana: Jurnal Kefarmasian
Kartini, Kartini
Faculty of Pharmacy University of Surabaya
Medicine & Pharmacology

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Formulation and physical stability test of oleanolic acid cream and gel Kartini, Kartini; Fitriani, Endang Wahyu; Tansridjata, Laurances
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.194 KB) | DOI: 10.12928/pharmaciana.v8i1.7336

Abstract

Plantago major has been empirically used for wound healing. One of its chemical compounds, oleanolic acid, exhibited wound healing activity on hyperglycemic rats. The aims of this study were to (1) formulate oleanolic acid into topical dosage forms i.e. cream and gel; and (2) evaluate the physical stability of the products. Oleanolic acid was formulated into the dosage forms using stearic acid, isopropyl palmitate and cetyl alcohol as the cream base and carbomer as the gel base. Cream and gel were then subjected into accelerated (40±2°C/75±5% RH) and room temperature (27±2°C/73±5% RH) stability test for six weeks. Physical stability was determined using parameters of visual appearance, specific gravity, viscosity and flow properties, for both gel and cream, as well as the type of emulsion and particle size for the cream. Data analysis were performed using one-way ANOVA and paired t-test. It is concluded that gel and cream of oleanolic acid were able to maintain their visual appearance, specific gravity, viscosity and flow properties during six weeks of storage. In addition, oleanolic acid cream could also maintain its particle size and type of emulsion during testing. 
Co-Authors Fitriani, Endang Wahyu Tansridjata, Laurances