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A Review on the Relationship Between p53 Gene and Viruses in Endometriosis: Tinjauan tentang Hubungan Antara Gen p53 dan Virus pada Endometriosis Khzal, Alaa Mahdy Obaid
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.130

Abstract

Ten percent of pre-menopausal women suffer from endometriosis which manifests as a chronic inflammatory disorder due to complicated and poorly understood pathogenesis. The relationship between P53 tumor suppressor genes and viral infections as causes of endometriosis needs complete evaluation in research. Studies conducted at the molecular level reveal endometriotic lesions display major P53 expression variations while functional regulation and defensive abilities change from somatic mutations and DNA polymorphisms in addition to epigenetic influences that block tumor-suppression operations. Multiple investigations have established that endometriotic tissues carry human papillomavirus (HPV) Epstein-Barr virus (EBV) and cytomegalovirus (HCMV) viral DNA sequences with varying frequency percentages. The proposed mechanisms study how viral oncoproteins activate P53 pathways in endometriosis development by damaging cell death systems and through their influence on inflammatory processes and genomic instability creation and cell motility changes. The review examines how such biological interactions impact endometriosis diagnosis and treatment options. Currently missing components of known analysis become apparent in this research as it points out needed study techniques for understanding the sophisticated relationship between sun-induced skin damage and Human Papillomavirus infections. Highlights: Endometriosis involves disrupted P53 function due to mutations, polymorphisms, and epigenetics. Viral DNA from HPV, EBV, and HCMV is found in endometriotic tissues, implicating infections in disease progression. Viral oncoproteins may alter P53 pathways, affecting inflammation, cell death, and genomic stability. Keywords: Endometriosis, P53 Tumor Suppressor, Human Papillomavirus, Viral Oncoproteins, Inflammation
The preoperative testing at laboratories in Najaf are being performed on patients at the time of the surgery in order to do this evaluation of blood-borne viruses Khzal, Alaa Mahdy obaid
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 4 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i4.406

Abstract

Al-Sadir Teaching Hospital, Najaf, Iraq was the surrounding for this study that was done during the window of time from the 1st of January to the 1st of November of the same year. A descriptive, cross-sectional, hospital-based study of hospitals is investigated. The research was conducted during January, 1st 2023 and November 1, 2023 in the course of studies. The project evlaution was launched on 21st of January and finalized on 1st of November. The purpose of this researched was to determine proportion of patients who were infected with the blood borne diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). All of these viruses are transmitted because the blood carries them. The technique was considered necessary to establish the amount of viral infection in these patients. ELISA testing was among the components, of the pre- surgical virus therapy, which was received by the patient and it was performed on the blood samples collected from the patient.Eventually we came to the conclusion that the procedures were applied as implied in the system. In our investigations, we determined that the Human Papilloma Virus (HPV) is the one virus that had been identified to be infecting the people whose cases were detected by the examination process. The second most well-known virus after Human Virus (HCV) that is also categorized as one of the human viruses is the Human and Human Immune Globaly Viruses complex (HIV). I state emphatically discrimination or age bias was non existent during data collection at any point in time of the whole process. I got the data together in a process which of a ten months' duration and took place solely in this particular educational organization. A total of 125 individuals were tested positive out of which 64 were affected by HBV, 60 (60%) got affected by HCV, and 7 (70%) were affected by HIV. The isolation of the virus was only possible when it was passed on by all male who were tested. The girls had a unique and admirable quality: not a single one of them tested positive for the infection. It was evident among the people affected that about two thirds were male. Actually, only less than 1/3 (30%) of the females getting tested HIV positive, whereas 5 (43.4%) of them had HBV and even 5 (45%) of them showed the HCV result Thus, it is evident with the result seen that the number of cases of women from prevention to men who visited the health center was much lower. We look forward to having 19,925 folks at the donation drive having filled up the collection tubes with their blood. Via the study of a total of 1,330 Hepatitis B virus cases, the test was found positive in (145) of them, and negative only in the (1205) remaining cases. By which implies gives us 19925 which is definitely it is the quantity of blood to be collected