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All Journal JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Muhammad Thifan Satyagraha
Fakultas Kedokteran Universitas Diponegoro
Health Professions Medicine & Pharmacology Public Health

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Lipid-based Nutrient Supplements Prenatal sebagai Tindakan Preventif Terjadinya Berat Badan Lahir Rendah dan Penurunan Fungsi Kognitif pada Bayi Muhammad Thifan Satyagraha; Rafi Annisa Ulum; Farhan Syafiq Fadhilah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.242

Abstract

Background: Stunting in Indonesia is still high. One of the risk factors is the incidence of low birth weight in infants. If not addressed, the quality of human resources in Indonesia will be low. Thus, giving Lipid-based Nutrient Supplements (LNS), which has been carried out by several countries in order to optimize low birth weight and infant cognitive, needs to be researched. This study aims to collect and analyze articles related to the effect of LNS in pregnant women on birth weight and cognitive power in infants. Methods: The design used is a literature review, articles were collected using the Google search engine through several data sources such as Pubmed, Science Direct, Proquest, Ministry of Health, and BPS RI. The criteria for the articles used are research journals with the Randomized Controlled Trial and Systematic Review methods published in 2015 - 2020. Discussion: Based on the articles, the results show that LNS given to pregnant women can increase body mass and increase brain volume in infants. This is caused by the Brain Specific Fatty Acid which includes docosahexaenoic acid (DHA) and arachidonic acid (ARA) which support tissue formation, immunity, and neurodevelopment. Conclusion: Giving LNS to areas where the prevalence of stunting is still high can be a solution to the problem of stunting in these areas. The suggestion from this research is to create an LNS program, especially in areas where the prevalence of stunting is still high.
HUMAN EMBRYONIC STEM CELL DERIVATIVE SUBRETINAL PIGMENT EPITHELIAL TRANSPLANTATION AS A TREATMENT FOR DRY-TYPE MACULAR Muhammad Thifan Satyagraha; Andhwika Afif Fahrezi; Rafi Annisa Ulum; Gibran Chandra Syarif Hidayatullah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.463

Abstract

Age-related Macular Degeneration (AMD), is the fourth disease which causes blindness in the world, will potentially increase in 2020. Therefore, alternative treatment is needed to be developed, such as Human Embryonic Stem Cell-derived Retinal Pigment Epithelium (hESC-RPE) transplantation in a subretinal layer. The purpose of this literature review is to identify AMD pathogenesis, especially dry type, to know the impact of hESC-RPE transplantation towards acuity of vision, and to understand its therapeutic effect, safety, also tolerability based on the literature cited. Articles were collected by google search engine through Pubmed, Sciencedirect, Proquest, and Springer link. Inclusion criteria are literature that was published between 2010-2020, clinical trial study, systematic review, and meta-analysis. the topic of these sources is focused on regenerative therapy in AMD patients. Whereas exclusion criteria are literature that published under 2010. According to our research, hESC-RPE transplantation in a subretinal layer can increase the acuity of vision in dry-type AMD patients by improving RPE pigmentation, which protects its photoreceptor cells. Safety and tolerability are proof that there are no abnormalities in proliferation and immunity. In conclusion, these findings are beneficial in the improvement quality life of AMD patients. Therefore, in the future, subretinal hESC-RPE can be effective in the alternative treatment of dry-typed AMD patients.
TOCILIZUMAB AS MONOCLONAL ANTIBODY THERAPY IN OVERCOMING ACUTE RESPIRATORY DISTRESS SYNDROME IN COVID-19 PATIENTS Muhammad Thifan Satyagraha; Graceanne Sheridan; Vito Etenio Ade Laryan; Gibran Chandra Syarif Hidayatullah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.488

Abstract

Acute respiratory distress syndrome (ARDS) as a clinical manifestation of severe pneumonia is a major cause of death for patients with coronavirus disease 2019 (COVID-19) who are treated in intensive care units (ICU). ARDS is triggered by cytokine storm. Cytokine storm is characterized by an increased in proinflammatory cytokines such as IL-6, IL-1?, and IL-1?. Thus, IL-6 and IL-1 cytokine inhibitors in the form of monoclonal antibodies are needed to overcome this. This review of the scientific literature aims to identify the effect of monoclonal antibody therapy, which is focusing on the inhibitors of cytokines IL-6 (tocilizumab) and IL-1 (anakira) in patients with severe pneumonia caused by severe acute respiratory coronavirus-2 (SARS-CoV-2) ) with clinical manifestations in the form of ARDS. The design used in the form of scientific literature review. Articles were collected via Google Scholar search engine through several data sources (Pubmed, Sciencedirect, Nature, Proquest, and Springer Link). Inclusion criteria used were literature sources published between 2011 – 2020 in the form of research articles, systematic reviews, annual reports, and/or books. Meanwhile, the exclusion criterion used was literature sources under 2011. Based on article search results, tocilizumab can efficiently improve clinical status and reduce the mortality rate of COVID-19 patients with ARDS. Even so, tocilizumab can increase the risk of infection and the evidence obtained by the authors was not enough to support the administration of tocilizumab outside of clinical trials. Thus, the safety and side effects of monoclonal antibodies need to be further investigated.
Co-Authors Andhwika Afif Fahrezi Farhan Syafiq Fadhilah Gibran Chandra Syarif Hidayatullah Graceanne Sheridan Rafi Annisa Ulum Rafi Annisa Ulum Vito Etenio Ade Laryan