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All Journal JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Abed Nego Okthara Sebayang
Program Studi Profesi Dokter, Fakultas Kedokteran Universitas HKBP Nommensen, Medan
Health Professions Medicine & Pharmacology Public Health

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EFEK KARDIOTOKSIK OBAT KEMOTERAPI DOXORUBICIN Abed Nego Okthara Sebayang
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 7 No 1 (2019): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 7.1 Edisi Januari - A
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v7i1.387

Abstract

Introduction: Doxorubicin is an anthracycline class antibiotic that is widely used for the treatment of various types of cancers such as acute leukemia, breast cancer, bone and ovarian cancer. This compound was isolated from streptomyces peucetius var caesius and was used extensively in the treatment of cancer. But doxorubicin has a fairly dangerous cardiotoxic effect. Myocardial dysfunction by the use of doxorubicin can occur due to the formation of free radicals that are harmful to the heart.Discussion: Doxorubicin is the most widely used anthracycline drug in cancer treatment. Side effects that often arise from the use of doxorubicin are cardiotoxic. Myocardial dysfunction caused by doxorubicin may be caused by free radicals formed, impaired adrenergic function, formation of lipid peroxides, impaired transport of Ca in the sarcollemma, release of TNF? and interleukin-2 and cytokines free of tumor tissue. The mechanism of oxidative stress is the mechanism that most often results in damage to the heart.Conclusion: Doxorubicin is an anthracycline drug that is widely used in cancer treatment. Doxorubicin has quite dangerous side effects, namely cardiotoxic. Cardiotoxics can cause heart failure. For this reason, a clinical approach must be taken in using doxorubicin to monitor the toxic effects.
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