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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Medical Laboratory Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Dzakiya Zhihrotulwida
Universitas Anwar Medika
Health Professions Nursing Public Health

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Review Artikel : Sediaan Steril Injeksi Miya Hartini Nur Wakhid; Fina Nikmatul W; Windi Tri Wahyuni; Rizki Amalia Putri; Dewi Nur Halisa; Magdalena Kasih Belaon Lebuan; Dewi Rahmawati; Dzakiya Zhihrotulwida; M. Fithrul Mubarak
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 1 (2025): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i1.506

Abstract

Sterile injection preparations are liquid pharmaceutical preparations that are specifically designed to be administered directly into the body through injection using a sterile syringe or clean injection device. The main requirement for sterile injection preparations is that they must be free from microorganisms, foreign particles, and pyrogenic substances that can trigger fever or infection reactions in patients. Testing the quality of sterile injection preparations includes various aspects, ranging from sterility testing, pyrogenicity testing, clarity testing, to stability testing during the shelf life. Stability testing aims to ensure that the preparation remains safe, effective, and stable until its expiration date. The purpose of this study was to determine the evaluation of sterile injection preparations. The method used is by reviewing journals from Google Scholar, Pubmed, etc. from 2018-2024.  
CPOB Sediaan Steril Dewi Rahmawati; Dzakiya Zhihrotulwida; M. Fitrul Mubarak; Ismatun Maulidiyah; Elsa Saqila; Aprilia Puji; Ika Hepi; Silvi Novita Permatasari
Calory Journal Medical Laboratory Journal Vol. 2 No. 4 (2024): December : Medical Laboratory Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/caloryjournal.v2i4.507

Abstract

The importance of Good Manufacturing Practices (GMP) in the pharmaceutical industry to ensure the quality and safety of drug products. GMP aims to ensure that all pharmaceutical preparations, including sterile drugs such as infusions and injections, meet strict quality standards. Sterility testing is an important aspect even though it has limitations, such as long incubation times and low probability of detecting contamination. Therefore, any sterility test results that do not meet the requirements must be further investigated to find the cause, either from laboratory errors or contamination in the production process. In addition, the implementation of technical and managerial aspects in accordance with GMP, such as temperature and humidity control, is very important to maintain product quality. This article also highlights the use of modern technologies, such as Service Oriented Architecture (SOA), to improve efficiency and transparency in the drug production process, so that it can meet all the provisions set.
Artikel Review : Efektivitas dan Keamanan Berbagai Rute Pemberian Obat Injeksi Suspensi Dila Alvia Rahmasari; Maulina Apriani; Amina Syifa; Dewi Febiyanti; Nurul Islami Ningtiyas; Nabilla Navyani Putry A; Dewi Rahmawati; Dzakiya Zhihrotulwida; M.Fithrul Mubarok
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2036

Abstract

Advances in technology and research in the field of pharmacy have driven innovation in drug formulation and administration methods to improve the effectiveness and safety of therapy. One of the most widely developed dosage forms is suspension injections, which are sterile preparations containing particles of active ingredients that are insoluble in the carrier fluid. This study aims to review the effects of various administration routes, such as intra-articular, intramuscular, and subcutaneous, on the efficacy and safety of suspension injections. The method used is a literature study analyzing various scientific journals from databases published in the last ten years. The results of the review show that the route of administration has a significant effect on the therapeutic effect, where the intra-articular route provides a strong local effect with low systemic risk, the intramuscular route produces long-term effects and is relatively easy to perform, while the subcutaneous route provides stable drug release over a long period of time. Overall, the choice of injection route for suspension injections should be tailored to the characteristics of the drug, the patient's condition, and the therapeutic goals to achieve optimal, safe, and comfortable treatment outcomes for the patient.
Co-Authors Amina Syifa Aprilia Puji Dewi Febiyanti Dewi Nur Halisa Dewi Rahmawati Dila Alvia Rahmasari Elsa Saqila Fina Nikmatul W Ika Hepi Ismatun Maulidiyah M. Fithrul Mubarak M. Fitrul Mubarak M.Fithrul Mubarok Magdalena Kasih Belaon Lebuan Maulina Apriani Miya Hartini Nur Wakhid Nabilla Navyani Putry A Nurul Islami Ningtiyas Rizki Amalia Putri Silvi Novita Permatasari Windi Tri Wahyuni