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Kintoko
Ahmad Dahlan University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

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Factors Creating Conflict in Small Traditional Medicine Yuniariana Pertiwi; Kintoko; Suliyanto; Nursanti; Septiana Indratmoko
Jurnal Penelitian Pendidikan IPA Vol 11 No 3 (2025): March
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i3.10581

Abstract

Conflicts are widespread in everyday life, whether in the home, at work, or in traditional medicine. Conflicts in the field of traditional medicine can arise as a result of numerous disagreements about the use of raw materials, manufacturing methods, and marketing strategies for herbal medicine, the presence of inappropriate job desks, the occurrence of role conflicts, horizontal conflicts, and interpersonal conflicts between managers and herbal medicine entrepreneurs. Until a legal matter reached the courtroom, the largest feud in history had occurred. The goal of this study is to identify the variables that contribute to conflict, which can then be used to resolve the conflict controversy in the field of traditional medicine in Cilacap Regency. This is qualitative research using a case study methodology. This study's respondents were employees of Small Traditional Medicine Enterprises (UKOT) in Cilacap Regency. Researchers collected data directly from participants using a questionnaire and in-depth interviews. Nonprobability sampling and snowball sampling were utilized. The findings indicate that communication, disparities in personal values, discrepancies in perception, and rewards are the primary causes of conflict at UKOT in Cilacap.
Molecular Mechanisms of Sechium edule Based on Network Pharmacology and Molecular Docking on Hypertension Rahmat Santoso; Kintoko; Nining Sugihartini
Jurnal Penelitian Pendidikan IPA Vol 12 No 2 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i2.14114

Abstract

Chayote is a fruit that has been used for centuries to treat various diseases, including hypertension. However, how the chemical compounds derived from chayote work in treating hypertension remains unclear. Integrating molecular docking and network pharmacology to elucidate the active constituents and potential mechanisms of chayote in treating hypertension. Initially, 50 active compounds from chayote and 97 key targets related to hypertension were identified through network pharmacology analysis. Then, the results of molecular docking and simulations showed: gibberellin A4; gibberellin A7; gibberellin A29; gibberellin A38; gibberellin A44; stigmasta-3,5-dien-7-one; stigmasterol and routinely overcome hypertension through the regulation of ACE, AKT1, ALB, SRC, and TNF genes. These compounds and genes may be key factors of chayote fruit in treating hypertension. Pathway enrichment analysis showed that the antihypertensive effect of chayote is regulated by the gibberellin A7 and TNF signaling pathways. These pathways are primarily associated with anti-oxidative stress, anti-inflammatory responses, and β-cell protection. This study identified the active constituents and potential signaling pathways involved in the antihypertensive effect of chayote. Result: These findings provide a theoretical basis for understanding the mechanism of the antihypertensive effect of chayote. Furthermore, this study may help develop health supplements or natural antihypertensive drugs based on chayote.
Co-Authors Nining Sugihartini Nursanti Rahmat Santoso Septiana Indratmoko Suliyanto Yuniariana Pertiwi