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All Journal Jurnal EduHealth JUKEJ: Jurnal Kesehatan Jompa
Lestari Putri
Universitas Swadaya Gunung Jati
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Clinicopathologic Features Of Langerhans Cell Histiocytosis At Hasan Sadikin Hospital In 2010-2020 P, Lestari
Jurnal EduHealth Vol. 15 No. 03 (2024): Jurnal EduHealt (September), Year 2024
Publisher : Sean Institute

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Abstract

Langerhans Cell Histiocytosis (LCH) is a rare neoplasm of myeloid origin, characterized by the proliferation of Langerhans cells expressing CD1a and CD207. While primarily affecting children, LCH can also occur in adults, though the incidence is extremely low. The disease manifests in various clinical forms, often complicating diagnosis and management. This study aims to describe the clinicopathological aspects of LCH cases treated at Hasan Sadikin Hospital (RSHS) Bandung over a ten-year period, from 2010 to 2020. Clinicopathological data of patients diagnosed with LCH at the Anatomical Pathology Department of Hasan Sadikin Hospital from 2010 to 2020 were retrospectively reviewed. Data collected included patient age, gender, anatomical location of the disease, and sampling methods used for diagnosis. Diagnosis of LCH was confirmed through morphological assessment of histopathologic specimens and fine needle aspiration biopsy (FNAB) smears. LCH remains a rare entity characterized by the abnormal proliferation of Langerhans cells, predominantly affecting children and most frequently involving the head region. Typical cytologic and histopathologic features are usually present, aiding in the diagnosis. However, variability in presentation underscores the importance of integrating clinical, radiologic, and immunohistochemical data for accurate diagnosis. Further research is warranted to explore long-term outcomes and optimal management strategies, particularly in regions with limited case data.
Gambaran Histopatologi pada Kanker Payudara Metastasis: Studi Cross-Sectional di Rumah Sakit Umum Daerah Waled Tahun 2020–2024 Salwa Hisana; Widiyatmiko Arifin Putro; Lestari Putri
JUKEJ : Jurnal Kesehatan Jompa Vol 5 No 2 (2026): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol5.Iss2.2724

Abstract

Kanker payudara merupakan salah satu jenis kanker yang paling sering terjadi pada wanita di Indonesia. Tingkat kelangsungan hidup pasien menurun secara signifikan setelah terjadi metastasis, dari sekitar 99% pada kasus lokal menjadi 27% pada kasus metastasis. Pemeriksaan histopatologi tetap menjadi standar emas dalam menegakkan diagnosis, menentukan terapi, dan memprediksi prognosis pasien. Penelitian ini bertujuan untuk mengetahui distribusi jenis histopatologi, grading tumor, dan lokasi organ metastasis pada pasien kanker payudara di Rumah Sakit Regional Waled periode 2020–2024. Penelitian menggunakan desain potong lintang dengan data sekunder melalui teknik total sampling dan dianalisis secara deskriptif. Dari 102 pasien kanker payudara metastasis, jenis histopatologi terbanyak adalah invasive carcinoma of no special type sebanyak 95 kasus (93,1%). Grading tumor yang paling banyak ditemukan adalah derajat III sebanyak 61 kasus (59,8%), sedangkan lokasi metastasis tersering adalah kelenjar getah bening sebanyak 67 kasus (52,3%). Hasil penelitian menunjukkan bahwa kasus kanker payudara metastasis didominasi oleh invasive carcinoma of no special type, grading derajat III, dan metastasis pada kelenjar getah bening.
Co-Authors Salwa Hisana Widiyatmiko Arifin Putro