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All Journal Cermin Dunia Kedokteran
Aiman Hilmi Asaduddin
Medical Doctor Profession Program, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia
Health Professions

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Eritema Nodosum Leprosum Berat pada Pasien Kusta Lepromatosa: Laporan Kasus Adelia Wuri Pramudita; Harijono Kariosentono; Annisa Marsha Evanti; Aiman Hilmi Asaduddin
Cermin Dunia Kedokteran Vol 51 No 12 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i12.1116

Abstract

A case of a 58-year-old woman with lepromatous leprosy and severe ENL reaction is reported. The patient has symptoms of pustules for 1 year and the nodules were getting worse in the last week, accompanied by fever, joint pain, nausea, and vomiting. Physical examination revealed madarosis, infiltrates of both ears, and multiple painful erythematous nodules on the extremities and trunk. Slit skin smear examination showed bacterial index +3 and morphological index of 15%. Histopathological examination revealed neutrophil infiltration and vasculitis in the upper dermis. The patient was diagnosed with lepromatous leprosy and severe ENL reaction. The patient received multidrug therapy and methylprednisolone (62.5 mg/day), which was gradually reduced. The ENL reaction is caused by the deposition of M. leprae antigens and antibodies in small blood vessels, resulting in vasculitis and the release of enzymes that damage tissues. ENL reactions are commonly found in multibacillary MH and occur before, during, and after treatment. This reaction is mediated by cytokines produced by T-helper-2 (Th2). ENL reactions can cause disability.
Co-Authors Adelia Wuri Pramudita Annisa Marsha Evanti Harijono Kariosentono