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All Journal Cermin Dunia Kedokteran
Sri Linuwih Menaldi
Department of Dermatology and Venereology Faculty of Medicine, University of Indonesia/RSUPN dr. Cipto Mangunkusumo Jakarta, Indonesia
Health Professions

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Patogenesis Melasma Riyantia Astrid Diahtantri; Sri Linuwih Menaldi; Fadhli Aulia Mughni
Cermin Dunia Kedokteran Vol 51 No 9 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i9.1514

Abstract

Melasma is a chronic skin pigmentation disorder caused by sunlight exposure. Melasma is a multifactorial disease with various pathways that can induce hyperpigmentation. Exposure to ultraviolet (UV) light as a source of reactive oxygen species (ROS) and free radicals plays a role in the pathogenesis of melasma. Another mechanism is the role of ROS on melanogenesis and melanocyte cells as well as the signaling pathway for melanin synthesis. Concentration of antioxidants as a skin defense against ROS, namely superoxide dismutase (SOD), catalase, and glutathione peroxidase, also influences the occurrence of melasma.
Co-Authors Fadhli Aulia Mughni Riyantia Astrid Diahtantri