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All Journal Damianus Journal of Medicine Journal SAGO Gizi dan Kesehatan
Ninik Mudjihartini
Departemen Biokimia dan Biologi Molekuler, Fakultas Kedokteran, Universitas Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Review literatur: Pengaruh media booklet dalam edukasi gizi pada pasien malnutrisi Siska Amelia; Wina Sinaga; Ninik Mudjihartini
Jurnal SAGO Gizi dan Kesehatan Vol 5, No 3A (2024): Agustus
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v5i3A.1741

Abstract

Background: Management of malnourished patients involves a process of nutritional counseling and education with the aim of increasing knowledge, food intake and nutritional status to help improve the patient's health.  As a form of non-video media, booklets contain educational material accompanied by graphic illustrations to help understand malnutrition patients.Objectives: This article aims to conduct literature reviews that explains the influence of booklets as a communication medium in the process of nutritional counseling and education and its impact on malnourished patients.Methods: The research design is of literature review on English language articles between 2013-2023, which were published in the most reputable journals in the field of nutrition (Nutrition Science) with the highest H-5 index. Search for articles via the internet from the PubMed database using the keywords malnutrition OR nutrition counseling OR nutrition education OR nutrition communications OR nutrition media OR nutrition booklet. To complete the results data, a search was also carried out for relevant Indonesian language literature to support elaboration and analysis.Results: 26 articles have been obtained discussing topics in the scope of malnutrition, nutritional counseling and education as well as related to the use of booklets as a media for nutritional education. Various previous research results state that selecting communication media and understanding the theory of changing individual health attitudes and behavior is an important part of the nutritional education and counseling process, where medical personnel must be able to build effective communication with malnourished patients. Booklets are a concise and practical communication medium for patients to read again, so they are proven to increase the effectiveness of patients' learning experiences and understandingConclusion: Booklets are an effective non-video media option and have a positive impact on improving the nutritional status of malnourished patients. It is recommended that stakeholders in health sector maximize the use of booklet media in nutritional counseling and education activities to help reduce the problem of malnutrition in Indonesia. 
Efek proteksi hipoksia hipobarik intermiten pada otak tikus: Analisis konsentrasi Caspase-3, Neutrophin-3, karbonil dan SOD Ninik Mudjihartini; Defli Yuandika Ruso; Wawan Mulyawan; Atikah Chalida Barasila; Yulhasri
Bahasa Indonesia Vol 25 No 1 (2026): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v25i1.6554

Abstract

Introduction: The brain is the largest energy-consuming organ in the body and is highly vulnerable to damage under hypoxic conditions. However, certain periods of hypoxia can be tolerated and provide protective effects. This study aimed to investigate the protective effects of intermittent hypobaric hypoxia (IHH) on the expression of caspase-3, neurotrophin-3, carbonyl, and superoxide dismutase (SOD) levels in rat brain tissues. Methods: A total of 25 male Wistar rats were divided into five groups: a control group (normoxic conditions) and four treatment groups exposed to hypobaric hypoxia in a chamber simulating 25,000 feet altitude for 5 minutes at intervals of 7 days for each exposure. Group 1 was exposed to a one-time hypoxia condition (IHH 1), group 2 was exposed two times (IHH 2), group 3 was exposed three times (IHH 3), and group four were exposed four times (IHH 4). Results: Caspase-3 levels significantly decreased in the treatment groups compared to the control group (p<0.05), indicating a positive response to IHH. In contrast, neurotrophin-3 and carbonyl levels showed no significant changes across the groups, maintaining a stable trend. Additionally, a significant increase in SOD levels was observed between group 1 and group 3 (p<0.05), suggesting enhanced antioxidant defense with repeated IHH exposure. Conclusion: Intermittent hypobaric hypoxia can suggest a protective effect against hypoxic damage by suppressing caspase-3 expression. Repeated IHH exposure enhances antioxidant defense by elevating SOD levels. In contrast, neurotrophin-3 and carbonyl levels remain unchanged, suggesting these markers are unresponsive to short-term IHH.
Co-Authors Atikah Chalida Barasila Defli Yuandika Ruso Siska Amelia Wawan Mulyawan Wina Sinaga Yulhasri