Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal BIOVALENTIA: Biological Research Journal
Dwi Hardestyariki
Department of Biology, Faculty of Mathematics & Natural Sciences, Sriwijaya University. Jalan Raya Palembang-Prabumulih km 32, Indralaya, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Molecular and Epigenetic Impacts of Pesticides on the Female Reproductive System: A Review Kamila Alawiyah; Dian Anggraini; Wildan Mubarok; Dwi Hardestyariki
BIOVALENTIA: Biological Research Journal Vol. 10 No. 1 (2024)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/biov.10.1.2024.434

Abstract

Pesticides, primarily originating from agricultural activities, have raised environmental and health concerns due to their suspected effects on the female reproductive system. Despite their widespread application, a significant research void exists concerning their implications for human female reproductive health. This review provides comprehensive information on the adverse effects of pesticides on female reproduction, focusing on their molecular and epigenetic mechanisms. In general, these adverse outcomes include ovarian dysfunction, hormonal irregularities, the onset of endometriosis, and an increased risk of stillbirths. From a mechanistic perspective, pesticides can interfere with the endocrine system, catalyze the formation of reactive oxygen species, and induce oxidative stress. At the molecular level, certain pesticides can act as hormone mimics, disrupting the normal hormonal balance. Moreover, they can trigger epigenetic shifts, leading to alterations in non-coding RNAs, histone configurations, and DNA methylation patterns. These epigenetic alterations not only have an immediate impact but can also be passed on to subsequent generations. Highlighting these concerns, this review underscores the urgent need for stringent regulations and aims to catalyze future in-depth studies on the relationship between pesticides and female reproductive health.
Co-Authors Dian Anggraini Kamila Alawiyah Wildan Mubarok