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All Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health
Safrina Dewi Ratnaningrum
Department of Anatomy Histology, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia
Health Professions Public Health

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Therapeutic Potential of Phaleria Macrocarpa Flavonoid Extract Regulating Rantes in Endometriosis Fany Hardiati Amalia; Amina Diarsy; Sutrisno Sutrisno; Safrina Dewi Ratnaningrum
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25587

Abstract

Endometriosis is a long-term inflammatory disease that affects women of childbearing age. It is caused by endometrial tissue growing in places other than the uterus. RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) and other important inflammatory mediators are very important in making the inflammatory responses related to this disorder worse. The aim of this study was to evaluate the impact of the ethanolic extract of flavonoids derived from the fruit of Phaleria macrocarpa (Mahkota Dewa) on RANTES levels in a rat model of endometriosis. Thirty female rats were divided into six groups: one healthy control group, one endometriosis control group, and four treatment groups that received doses of 3.75, 7.5, 15, and 30 mg/rat/day of the extract, respectively. The endometriosis model was established by transplanting myometrial and endometrial tissues from a patient with adenomyosis into the peritoneal cavity of immunosuppressed rats. Once the model was set up, the rats got the extract every day for 15 days in a row. We used the ELISA method to measure RANTES levels and histological and immunohistochemical analyses to look at ERβ expression. The results showed that the endometriosis control group (K+) had the highest levels of RANTES (64.05 ? 1.86 pg/mL). Surprisingly, the group that got 30 mg/rat/day (P4) had the biggest drop in RANTES levels (45.95 ? 1.07 pg/mL). Moreover, an upregulation of ERβ expression was observed in rats with induced endometriosis, evidenced by intensified brown staining, succeeded by a dose-dependent reduction, signifying modulation of estrogenic activity. In summary, the administration of the ethanolic flavonoid extract from Phaleria macrocarpa significantly reduced RANTES levels in rats with endometriosis, underscoring its potential as an alternative treatment for managing inflammation related to endometriosis.?Keyword: Keywords: Phaleria macrocarpa, flavonoid, endometriosis, RANTES
Therapeutic Effect of Phaleria macrocarpa Flavonoid Extract on TGF-β Modulation in Endometriosis Mice Model Novrida Ratna Dewi; Cyntia Hemas Febrina Putri; Sutrisno Sutrisno; Safrina Dewi Ratnaningrum
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25544

Abstract

Endometriosis is a chronic estrogen-dependent inflammatory disorder characterized by ectopic endometrial-like tissue growth and dysregulated immune responses. Transforming Growth Factor Beta (TGF-β), although classically known as a profibrotic cytokine, also exhibits context-dependent anti-inflammatory activity, creating uncertainty regarding its net impact on endometriotic progression. This gap in the literature highlights the need to investigate agents that may modulate TGF-β in a controlled experimental setting. Phaleria macrocarpa, a flavonoid-rich medicinal plant, has demonstrated immunomodulatory potential, yet its relationship with TGF-β regulation in endometriosis remains poorly understood. This study aimed to evaluate the effect of Phaleria macrocarpa flavonoid extract on TGF-β levels in a Balb/C mouse model of endometriosis. A true experimental post-test only controlled design was conducted using 30 mice divided into six groups: negative control, positive control, and four treatment groups receiving 3.75, 7.5, 15, or 30 mg/mouse/day for 14 days. TGF-β levels were quantified using ELISA and analyzed with ANOVA followed by Tukey’s post-hoc test. The results demonstrated a non-linear dose–response pattern, with the 7.5 mg/mouse/day dose producing the highest increase in TGF-β, while higher doses showed attenuated or reduced responses. These findings indicate a biphasic modulatory effect of Phaleria macrocarpa flavonoids on TGF-β, suggesting a dose-dependent immunoregulatory influence that warrants further investigation. Keywords: Phaleria macrocarpa, TGF-β,  Endometriosis,  Mice.
Co-Authors Amina Diarsy Cyntia Hemas Febrina Putri Fany Hardiati Amalia Novrida Ratna Dewi Sutrisno Sutrisno Sutrisno Sutrisno