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Pengaruh Pemberian Ekstrak Buah Honje Hutan (Etlingera hemisphaerica Blume) terhadap Pemulihan Hiperkolesterolemia dan Hipertrigliseridemia pada Mencit (Mus musculus) Susanti; Aceng Ruyani; Euis Nursa’adah
Jurnal Biosilampari : Jurnal Biologi Vol 6 No 2 (2024): Biosilampari: Jurnal Biologi
Publisher : Universitas PGRI Silampari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62112/biosilampari.v6i2.84

Abstract

This study aimed to test the ethanol extract of honje fruit (Etlingera hemisphaerica) in regulating total cholesterol (CT) and triglyceride (TG) levels in mice (Mus musculus).  This study was a limited clinical trial with trials measuring CT and TG levels before and after treatment. measurement of CT and TG levels using four treatment groups (1 control, 2 doses of E. Hemisphaerica  Fruit Ethanol Extract (EEBE) and 1 dose of simvastatin), and each group was replicated by 5 M. musculus. The pathological condition is carried out with high-fat feeding for 10 days. The extract given consisted of two doses of EEBE, namely (0.26 and 0.39) mg / dL body weight (BB), and a comparison drug dose (simvastatin 0.52 mg / dL BB). Data collection has been carried out before and after EEBE administration for 13 days. Based on the BNT test, the average CT levels of the 4 treatment groups before treatment were 198.6 mg / dL and CT levels after treatment were 196.0 mg / dL, then the average TG levels before treatment were 160.2 mg / dL and after treatment was 158.4 mg / dL. While in treatment group 2 with EEBE dose (0.39 mg / g BB) experienced a decrease in CT levels before treatment namely (225.4 mg / dL) until after treatment namely (201.2 mg / dL) by 10.7% and also experienced a decrease in TG levels from before treatment ie (304.2 mg / dL) to after treatment ie (289.2 mg / dL) by 5%.  Based on the results of the study, it was concluded that giving EEBE to potentially reduce CT and TG levels in M. musculus test animals in the three treatment groups.