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All Journal Jurnal Biosains Pascasarjana RESLAJ: Religion Education Social Laa Roiba Journal
Ambarioni, Agnes
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Social Sciences

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ALTERNATIVE MATRICES FROM THE ORAL CAVITY AS A SOURCE FOR DRUG DETECTION Ambarioni, Agnes; Prayudha, Anggy
Jurnal Biosains Pascasarjana Vol. 27 No. 1 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i1.2025.65-75

Abstract

Forensic toxicology plays a crucial role in law enforcement by detecting xenobiotic substances in the human body, aiding in legal decisions. Traditional matrices like blood and urine have significant drawbacks, such as invasiveness, susceptibility to adulteration, and limited detection windows. This paper explores alternative matrices from the oral cavity, including oral fluid, teeth, dental plaque, and dental calculus, for drug detection. Oral fluid offers non-invasive collection and reliable pharmacokinetic data, while teeth provide long-term drug detection in postmortem cases. Dental plaque and dental calculus can trap substances over time, offering insights into past drug use with less invasive sampling. These matrices reflect the overall condition of the body and provide valuable forensic information. Continued research and technological advancements are necessary to optimize their application in various forensic scenarios.
Medicinal Substance Detection from Archaeological Dental Calculus Ambarioni, Agnes
Reslaj: Religion Education Social Laa Roiba Journal Vol. 7 No. 3 (2025): RESLAJ: Religion Education Social Laa Roiba Journal
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/reslaj.v7i3.6473

Abstract

Dental calculus is mineralized dental plaque adhering to tooth surfaces. During the process of mineralization, materials from saliva and the oral cavity are preserved within its layers. Recently, the ability of preservation, withstand time and harsh environment, made dental calculus an emerging topic in archaeological studies. Through the advancement of technology, dental calculus offers a valuable resource for exploring past human behavior, including health, diet, and medicinal practices. Although the study of archaeological dental calculus has been ongoing for many years, investigations of medicinal compounds are still underexplored. This paper aims to identify and analyze the use of medicinal substance to gain valuable insights of past healthcare systems, treatment methods, and the interaction between medicinal substances and culture. Studies have revealed the presence of medicinal plants, animal products, minerals, and metabolites from ancient dental calculus. The discovery also led to the understanding of habitual and cultural practice such as treatments through special diets and the practice of trades. However, challenges still remain, including distinguishing between intentional and accidental substance use, overcoming gaps in historical records, and addressing the underrepresentation of specific regions and eras. These limitations highlight the need for future research so we can deepen our understanding of historical medicine, contribute to preserving cultural knowledge, and shaping modern pharmacological practices.
Co-Authors Prayudha, Anggy