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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Bayu Nugroho , Ardiansah
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Antifungal Ability as an Antimicrobial of Eucalyptus Oil (Melaleuca leucadendra) in Inhibiting the Growth of Candida albicans Retnowati, Wiwin; Abdillah, Ichsan; Bayu Nugroho , Ardiansah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2485

Abstract

The Indonesian community recognizes eucalyptus oil as one of the traditional medicines. Eucalyptus oil is known for its antimicrobial properties, which are antibacterial, antivirus, and antifungal. This study aimed to determine the antifungal effect as an antimicrobial of eucalyptus oil (Melaleuca leucadendra) produced by MSME Sendang Arum Lamongan in inhibiting the growth of Candida albicans. The research used a true experimental post-test-only control group design with the antifungal diffusion test method. Sampling was done by simple random sampling with eucalyptus oil concentrations of 20%, 40%, 60%, 80%, and 90%. The data obtained was inhibition zone diameter, which was analyzed using IBM SPSS statistics 26 software. In this study, the diameter of the inhibition zone of positive control, negative control, 40% concentration, 60% concentration, 80% concentration, and 90% concentration was 19.63 mm, 0.00 mm, 26.36 mm, 41.15 mm, 49.69 mm, 56.09 mm, 61.36 mm, respectively. Non-parametric statistical analysis using the Kruskal-Wallis test obtained p<0.05, indicating an effect between eucalyptus oil (M.leucadendra) on the ability to inhibit the growth of Candida albicans. The Post-Hoc test with Dunnet  T3 found that the concentration of eucalyptus oil 40%, 60%, 80%, and 90% had significant differences from the positive control (Nystatin 100 IU). Eucalyptus oil can inhibit the growth of Candida albicans. Therefore, eucalyptus oil has great potential as an alternative or adjunctive therapy for treating candidiasis caused by Candida albicans.
Co-Authors Abdillah, Ichsan Wiwin Retnowati