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All Journal International Journal of Health Literacy and Science
Novita, Novita Dian Susilowati
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Education Environmental Science Health Professions Public Health Social Sciences

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Topical Antibiotic Optimization of Wijayakusuma Plant (Epiphyllum oxypetalum) as Mosquito Repellent Therapy Oil Agus Darwanto, Agus Darwanto; Rindi, Kis Rindiana Subroto; Novita, Novita Dian Susilowati
International Journal of Health Literacy and Science Vol. 1 No. 1 (2023): International Journal of Health Literacy and Science
Publisher : Health Science UDINUS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60074/ihelis.v1i1.1

Abstract

Wijayakusuma plants contain various active compounds that are beneficial to health, such as alkaloids, triterpenoids, and saponins. This research aims to optimize topical antibiotic products from Wijayakusuma plant that were synergized with Sambung Nyawa, Sambang Darah, Bratawali, Sambilata, and Tobacco leaves into a therapeutic oil for a mosquito repellent. The topical antibiotics were made by maceration method by soaking wijayakusuma, sambung nyawa, sambilata, bratawali, sambang getih, and tobacco leaves using VCO then tested by viscosity test, antibacterial test, phytochemical screening, antioxidant test, and efficacy test. Data were analyzed with descriptive statistics. The results showed that viscosity measurement with Oswald 20oC showed 22.56 cP. Antioxidant analysis used the % DPPH inhibition method with a sample of 50,000 ppm was 51.6%. Antibacterial activity against Bacillus subtilis (grampositive) was 18.8 mm (strong), and against Escherichia coli (gram-negative) was 10.4 mm (strong). The equivalent flavonoids as topical antibiotics contained 15.51 mg QE/ml, phenolics 8.11 mg GAE/ml, and tannins 11.30 mg TAE/ml. Mosquitoes stumbled and flew away when exposed to this topical antibiotic. This topical antibiotic has good antioxidant content for body care, antibacterial and aromatherapy that repels mosquitoes, and is suitable for external massage oil treatment.
Co-Authors Agus Darwanto, Agus Darwanto Rindi, Kis Rindiana Subroto