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All Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Pijar MIPA
Sandrawati, Neny
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Molecular Docking and Pharmacoinformatics Study of Bioactive Compounds in Sweet Flag (Acorus calamus L.) as Antidiabetic Agents Targeting α-Glucosidase Nasution, Rani Sakila; Dewata, Indang; Yuhelman, Nofri; Sandrawati, Neny; Kusnanda, Arif Juliari
Jurnal Pijar Mipa Vol. 20 No. 4 (2025): Special Issue
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i4.8994

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder whose prevalence continues to rise, necessitating safer and more effective therapeutic alternatives. This study aims to explore the potential of active compounds from the calamus plant (Acorus calamus L.) as candidates for α-glucosidase enzyme inhibitors using an in silico approach. Pharmacokinetic screening, toxicity prediction, and Lipinski's Rule of Five screening were conducted to assess the pharmacological suitability of the compounds, followed by molecular docking using MOE 2022 software. The results of the study showed that several compounds from the jeringau plant (Acorus calamus L.), such as galgravin and veraguensin, have strong binding affinity to the α-glucosidase enzyme with docking scores of −8.40 kcal/mol and −8.37 kcal/mol, respectively. Pharmacokinetic prediction results indicate that the test compounds have good absorption and meet druglikeness criteria. This study suggests that active compounds from jeringau have potential for development as natural-based antidiabetic agents. However, this research is limited to computational analysis without experimental data support, and compound selection is based on GC-MS results without further isolation or characterization. Further studies through in vitro and in vivo testing, as well as molecular dynamics simulations and ADMET predictions, are required to validate these findings comprehensively.
Penguatan literasi kosmetik aman guru MGMP kimia Kota Padang melalui edukasi dan pelatihan Sandrawati, Neny; Thaitami, Siti Hajar; Away, Romy Dwipa Yamesa; Stiadi, Della Rosalynna
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 10, No 1 (2026): February
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v10i1.36631

Abstract

Abstrak Peredaran kosmetik ilegal tanpa izin Badan Pengawas Obat dan Makanan (BPOM) yang mengandung bahan berbahaya seperti merkuri, hidrokuinon, dan rhodamin masih menjadi permasalahan kesehatan masyarakat. Kosmetik ilegal berpotensi menimbulkan dampak toksik akut maupun kronis bagi penggunanya. Dalam konteks tersebut, Guru Musyawarah Guru Mata Pelajaran (MGMP) Kimia Kota Padang memiliki peran strategis sebagai agen literasi kimia, namun penguatan kapasitas melalui peningkatan pengetahuan dan pelatihan teknis masih diperlukan untuk mendukung kemampuan identifikasi kosmetik yang aman dan legal. Program pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan guru mengenai bahaya kosmetik ilegal, keterampilan membaca label, kemampuan mengecek legalitas melalui aplikasi BPOM, serta pemahaman teknik penggunaan kosmetik yang benar sesuai jenis kulit. Kegiatan ini melibatkan 40 orang guru. Tahapan pelaksanaan kegiatan meliputi penyuluhan oleh narasumber, pelatihan terstruktur, dan simulasi praktik langsung yang diikuti oleh peserta. Hasil program pengabdian masyarakat menunjukkan hasil yang positif, dengan peningkatan signifikan pada pengetahuan dan keterampilan peserta, tercermin dari naiknya skor pada 11 dari 15 pertanyaan pre-test dan post-test (p < 0,05). Kegiatan ini terbukti efektif memperdalam pemahaman peserta mengenai risiko kosmetik ilegal, cara menilai label dan bahan berbahaya, serta penggunaan aplikasi BPOM Mobile, sehingga mendorong peningkatan kesadaran dalam memilih produk kosmetik yang aman. Kata kunci: BPOM; guru; kosmetik ilegal; merkuri. Abstract The circulation of illegal cosmetic products without authorization from the Indonesian Food and Drug Authority (BPOM), which often contain hazardous substances such as mercury, hydroquinone, and rhodamine, remains a significant public health concern. These products may cause both acute and chronic toxic effects in users. In this context, teachers of the Chemistry Subject Teachers’ Association (MGMP) in Padang City play a strategic role as agents of chemical literacy; however, strengthening their capacity through enhanced knowledge and technical training is still required to support their ability to identify safe and legally approved cosmetic products. This community service program aimed to improve teachers’ knowledge of the risks associated with illegal cosmetics, skills in reading product labels, ability to verify product legality using the BPOM Mobile application, and understanding of proper cosmetic use according to skin type. The program involved 40 chemistry teachers and was implemented through several stages, including educational lectures, structured training sessions, and hands-on practice simulations. The results demonstrated a positive impact of the program, with a significant improvement in participants’ knowledge and skills, as reflected by increased scores in 11 out of 15 pre-test and post-test questions (p < 0.05). Overall, the program was effective in enhancing participants’ understanding of the risks of illegal cosmetics, methods for evaluating labels and hazardous ingredients, and the use of the BPOM Mobile application, thereby promoting greater awareness in selecting safe cosmetic products. Keywords: BPOM; teacher; illegal cosmetic; mercury.
Pemberdayaan masyarakat Nagari Dalko melalui hilirisasi produk sabun herbal kayu manis Tasman, Anggela Marta; Sari, Yuni Mala; Andriani, Fivit; Sandrawati, Neny; Stiadi, Della Rosalynna
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 10, No 1 (2026): February
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v10i1.36623

Abstract

Abstrak Nagari Dalko memiliki potensi pertanian yang melimpah, salah satunya adalah kayu manis (Cinnamomun burmannii). Namun saat ini, potensi kayu manis belum di manfaatkan secara optimal. Oleh karena itu, kegiatan pengabdian masyarakat melalui program integrasi prodi dan nagari dilaksanakan dengan tujuan untuk meningkatkan nilai tambuh kayu manis sebagai upaya mendukung pengembangan pariwisata berbasis produk lokal di Nagari Dalko. Kegiatan ini meliputi pemberian materi mengenai sabun herbal, pelatihan pembuatan sabun herbal transparan dengan berbahan aktif kulit manis serta packaging sabun herbal. Kegiatan ini di ikuti oleh dua puluh masyarakat dari Nagari Dalko. Hasilnya masyarakat sangat mendukung adanya pelatihan pembuatan sabun herbal. Hal itu didukung oleh data angket yang menunjukkan bahwa tingkat pemahaman masyarakat Nagari Dalko mengenai sabun herbal awalnya hanya sekitar separuh responden yang mengetahui bahwa sabun dapat dibuat dari bahan alami seperti kayu manis (50%) dan yang memahami manfaat kayu manis bagi kesehatan kulit (60%). Namun, meningkat secara signifikan mencapai 90% dan 95%. Begitu pula dengan pemahaman bahwa sabun herbal lebih ramah di kulit, yang naik dari 80% menjadi 95%. Pengalaman responden dalam menggunakan sabun herbal juga meningkat dari 45% menjadi 70%, menunjukkan adanya minat baru untuk mencoba produk lokal berbahan alami. Ini menjadi peluang bagi masyarakat untuk meningkatkan pengetahuan, keterampilan sekaligus mendukung pengembang perekonomian parawisata bagi kemajuan Nagari Dalko. Kata kunci:  antibakteri; cinnamomum; pariwisata; sabun herbal; transparant. Abstract Nagari Dalko has abundant agricultural potential, one of which cinnamon (Cinnamomun burmannii). However, the potential of cinnamon has not been optimally utilized. Therefore, community servise activities through the study program and village integration program are carried out with the aim of improving the added value of cinnamon as an effort to support the development of local product-based tourism in Nagari Dalko. This activity includes providing material related to herbal soap, making transparent herbal soap with cinnamon as the active ingredient and herbal soap packaging. This activity was attended by twenty people from Nagari Dalko. The result showed that participant was supportive of herbal soap making training. This is supported by questionnaire data which shows that the level of understanding of the Nagari Dalko participants regarding herbal soap was initially Only about half of the respondents knew that soap could be made from natural ingredients such as cinnamon (50%) and understood the benefits of cinnamon for skin health (60%). However, it increased significantly to reach 90% and 95%. Similarly, the understanding that herbal soap is gentler on the skin increased from 80% to 95%. Respondents' experience using herbal soap also increased from 45% to 70%, indicating a renewed interest in trying local, natural products. This provided an opportunity for the participant to improve their knowledge and skill while supporting the development of the tourism economy for the progress of Nagari Dalko. Keywords: antibacterial; cinnamomum; herbal soap; tourism; transparent.
Co-Authors Andriani, Fivit Away, Romy Dwipa Yamesa Della Rosalynna Stiadi Indang Dewata Kusnanda, Arif Juliari Nasution, Rani Sakila Nofri Yuhelman Sari, Yuni Mala Siti Hajar Thaitami Tasman, Anggela Marta