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All Journal Journal of Advances in Medicine and Pharmaceutical Sciences
Nguyễn Ngọc Mai Thảo
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Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Nursing Public Health

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Pharmacological Properties and Standardization of Ngoc Linh Ginseng using Ultrasonic-Assisted Extraction Trung Phung-Van; Nguyễn Ngọc Mai Thảo; Nguyen Tan Thuong
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 1: May 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0401.778

Abstract

This study aims to evaluate the pharmacological potential and standardize the bioactive compounds of Ngoc Linh Ginseng (Panax vietnamensis) as a candidate phytopharmaceutical. The study was conducted throughout 2024 using a multidisciplinary approach, including ultrasonic extraction, chemical analysis, and pharmacological tests. Samples were collected from the Kon Tum and Quang Nam mountains, Vietnam, then extracted by the Ultrasonic-Assisted Extraction (UAE) method using ethanol-water solvents. The total saponin content obtained was analyzed using High Performance Liquid Chromatography (HPLC), resulting in a level of 28.5% with the identification of the main ginsenosides Rg1 and Re. Pharmacological activity was tested in vitro on LPS-induced RAW 264.7 cells, showing a decrease in pro-inflammatory cytokine production by up to 50% and strong antioxidant activity with an IC50 value of 25 µg/mL. In vivo tests on Wistar rats showed a hepatoprotective effect against liver damage caused by a high-fat diet. These results support the potential of Ngoc Linh Ginseng as a candidate for plant-based therapy. Further studies are recommended to explore the pharmacokinetics, clinical efficacy, and optimization of extraction techniques to expand its therapeutic applications.
Urbanization and the Rising Burden of Diabetes Mellitus through an Epidemiological Analysis of Urban Population Risk Factors Nguyễn Ngọc Mai Thảo; Huy-Thanh Nguyen; Quang Cuong Tran
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 5 No 1: May 2026
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0501.1029

Abstract

This research investigated how diabetes spreads and what triggers it within Vietnam’s urban centers. Our team used a quantitative cross-sectional design to get a clear epidemiological snapshot. Between January and April 2025, the gathered data from 1,250 residents across Hanoi, Ho Chi Minh City, and Da Nang. A direct measurement of BMI, waist-to-hip ratios, and fasting blood glucose, while also using questionnaires to track participant lifestyles. To round out the analysis, we pulled secondary figures from WHO databases and national health reports. The results are concerning. By 2025, diabetes prevalence in these cities hit 7.2%, but prediabetes is the bigger story, affecting 14.8% of the population. Geographically, Ho Chi Minh City leads with an 8.2% rate, followed by Hanoi at 6.9% and Da Nang at 6.0%. When looking at why these numbers are climbing, obesity (OR 3.45) and sedentary habits (OR 2.80) stand out as the primary culprits, alongside hypertension and genetics. It is clear that Vietnam’s rapid shift to urban living is driving this metabolic crisis. Moving forward, we need deeper research into how long-term city environments and changing diets specifically accelerate this disease.
Co-Authors Huy-Thanh Nguyen Nguyen Tan Thuong Quang Cuong Tran Trung Phung-Van