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All Journal Proceeding ISETH (International Summit on Science, Technology, and Humanity) Biomedika
Anggreheni, Putri Dwi
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Engineering Medicine & Pharmacology Social Sciences Other

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Managing Pulmonary Edema and Electrolyte Imbalance in Advanced Chronic Kidney Disease: A Case Report Anggreheni, Putri Dwi; Suryaningsih, Retno
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5532

Abstract

Background: Chronic kidney disease (CKD) is a progressive disorder that leads to fluid overload and electrolyte imbalances, increasing the risk of pulmonary edema, hyperkalemia, and hyponatremia. These complications contribute to high morbidity and mortality, necessitating a multidisciplinary approach for optimal management. Case Descriprion: A 74-year-old female with stage V CKD presented with acute respiratory distress and severe dyspnea due to pulmonary congestion. Laboratory tests revealed hyperkalemia (6.76 mEq/L), hyponatremia (129 mEq/L), and metabolic acidosis. Chest X-ray confirmed bilateral pulmonary edema, while ECG showed peaked T waves, indicating potassium-induced cardiac instability. Initial management with loop diuretics failed, requiring urgent hemodialysis for fluid removal and electrolyte correction. Calcium gluconate, insulin-dextrose, and potassium binderswere used to control hyperkalemia, while fluid restriction and slow sodium correction were implemented for hyponatremia. The patient showed significant improvement within 48 hours, with stabilization of respiratory function and electrolyte levels. Discussion: Pulmonary edema in CKD results from volume overload, RAAS activation, and endothelial dysfunction, while electrolyte imbalances arise from impaired renal excretion. Management involves diuretics, dialysis, and targeted electrolyte correction. Emerging therapies such as SGLT2 inhibitors and novel potassium binders offer promising outcomes. Conclusion: This case highlights the importance of early intervention, hemodialysis, and precise electrolyte management in CKD patients with pulmonary edema. Future research should focus on personalized nephroprotective strategies to enhance patient outcomes.
Potential of Natural Larvicide Microemulsion Based on Pomegranate Peel Extract (Punica granatum L) against Dengue Haemorrhagic Fever Vectors Wahyuni, Sri; Aisyah, Riandini; Bestari, Rochmadina Suci; Ryanuranti , Rahma Ghaida; Anggreheni, Putri Dwi
Biomedika Vol 17, No 1 (2025): Biomedika Februari 2025
Publisher : Universitas Muhammadiyah Surakarta

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Background: Dengue fever, caused by the dengue virus which is transmitted by the Aedes aegypti mosquito, is a significant global health problem. Controlling the Aedes aegypti vector is key in efforts to reduce the spread of this disease. However, the use of chemical larvicides in vector control has raised concerns regarding environmental impacts and mosquito resistance. Therefore, research related to the development of natural larvicides based on pomegranate peel extract contain flavonoids, terpenoids, tannins, steroids, and saponins, in microemulsion form has an urgency to provide a safer and more sustainable alternative. Objective: To determine the larvicidal activity of microemulsion ethanol extract of pomegranate peel (Punica granatum) against Aedes Aegypti larvae. Methods: This research uses an experimental study design, post-test only controlled group design. The samples used were Aedes aegypti larvae instar III-IV. There were 12 treatment groups consisting of positive control, negative control, and treatment groups with microemulsion ethanol extract and ethyl acetate fraction of pomegranate peel extract, each with five different concentrations. Results: The probit analysis results indicate that the LC50 (Lethal Concentration for 50% mortality) for the ethanol extract microemulsion of pomegranate peel is 51,607 ppm, while the LC50 for the ethyl acetate fraction microemulsion of pomegranate peel is 52,401 ppm against Aedes aegypti larvae. Conclusion: the probit analysis shows that the ethanol extract microemulsion of pomegranate peel is slightly more effective in killing Aedes aegypti larvae compared to the ethyl acetate fraction microemulsion. These results emphasize the potential of pomegranate peel extracts as natural larvicides, contributing to sustainable and environmentally friendly mosquito control measures.  
Co-Authors Riandini Aisyah Rochmadina Suci Bestari Ryanuranti , Rahma Ghaida Sri Wahyuni Suryaningsih, Retno