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All Journal Science Midwifery Prosiding Seminar Nasional Program Pengabdian Masyarakat
Rahmawati, Suci Nur
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : science midwifery

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Dioscorea alata enhances on the corpus luteum histology in an endometriosis mouse model Makiyah, Sri Nabawiyati Nurul; Rahmawati, Suci Nur
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2301

Abstract

Endometriosis is a chronic inflammatory disease that causes ovarian damage and infertility. Dioscorea alata contains anti-inflammatory and antioxidant agents. This study examined the effect of ethanol extract of Dioscorea alata (EEDA) on the histology of corpus luteum in an endometriosis mouse model. This research is a quasi-experimental with a post-test-only controlled group design. Twenty-four mice were divided into six groups: control (C), negative control (NC) induced endometriosis model, positive control (PC) induced endometriosis model and letrozole, and three treatment groups induced endometriosis model and EEDA 50, 250, and 500 mg/kg body weight (T1, T2, T3). The number and diameter of corpus luteum analyzed with Kruskal-Wallis test, One-way ANOVA, and Duncan's test. The number of corpus luteum decreased in negative control group and increased significantly in the treatment groups (P = 0.038). The diameter of corpus luteum decreased in the negative control group and increased non-significantly in the treatment groups (P = 0.206). The conclusions of this research prove that EEDA has a positive effect both the number and diameter of corpus luteum in an endometriosis mouse model.
Co-Authors Achmadi, Rahma Amalina Adittya, Yudha Wisnu Anataya, Ivana Arya, Krishna Azizah, Citra Yuridha Nur Naufaldy, Aqillah Nabil Pranowo, Galih Yudo Rahayu, Galuh Kurniawati Rokhan, Muhammad Nurkholis SN Nurul Makiyah Sundari, Sri