Tujuan penelitian ini adalah untuk mengetahui dan menelaah efektivitas penegakan hukum tindak pidana pencemaran nama baik di Kepolisian Resort Kabupaten Gowa; dan menganalisa hal-hal yang berpengaruh terhadap keefektifan penegakan hukum tindak pidana pencemaran nama baik di Kepolisian Resort Kabupaten Gowa. Tipe penelitian ini yaitu penelitian desktiptif dengan pendekatan yuridis-empiris. Hasil yang diperoleh menunjukkan bahwa: (1) Penegakan hukum tindak pidana pencemaran nama baik di Kepolisian Resort Kabupaten Gowa terlaksana kurang efektif, terutama yang diatur pada Pasal 27 ayat (3), Pasal 28 ayat (1), dan Pasal 36. Demikian juga pemberian sanksi tindak pidana pencemaran nama baik dilihat dari perspektif hukum pidana yang diatur pada Pasal 51 ayat (2), Pasal 52 tindak pidana pencemaran nama baik; dan (2) Faktor substansi hukum, pengetahuan hukum, kesadaran hukum, perkembangan Iptek kurang berpengaruh terhadap efektivitas penegakan hukum tindak pidana nama baik di Kepolisian Resort Kabupaten Gowa. The purpose of this study is to determine and examine the effectiveness of law enforcement for criminal defamation in the Gowa District Police Resort; and to analyze the factors that influence the effectiveness of law enforcement for criminal defamation in the Gowa District Police Resort. This type of research is descriptive research with a juridical-empirical approach. The results obtained indicate that: (1) Law enforcement for criminal defamation in the Gowa District Police Resort is not effective, especially those regulated in Article 27 paragraph (3), Article 28 paragraph (1), and Article 36. Likewise, the imposition of sanctions for criminal defamation is seen from the perspective of criminal law regulated in Article 51 paragraph (2), Article 52 criminal defamation; and (2) Factors of legal substance, legal knowledge, legal awareness, and the development of science and technology have little influence on the effectiveness of law enforcement for criminal defamation in the Gowa District Police Resort.