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All Journal Journal Orthopaedi and Traumatology Surabaya (JOINTS) Acta Neurologica Indonesia
Yong, Yee Wen
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Health Professions Medicine & Pharmacology Neuroscience Public Health

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Comprehensive Analysis of Histamine-2 Receptor Antagonists on Dementia Risk: A Systematic Review of Cohort Studies Yong, Yee Wen; Puspitasari, Vivien
Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i02.68

Abstract

Introduction : Histamine-2 Receptor Antagonist (H2RA) are widely used to manage upper gastrointestinal diseases (UGID). However, growing concerns have emerged regarding their potential neurocognitive side effect, particularly an increased dementia risk. H2RAs are often preferred over proton pump inhibitors (PPIs) for enhanced therapeutic efficacy in clinical settings. Material and methods : This research adhered to the PRISMA guidelines to select studies and assess biases. Databases (PubMed, Scopus, and Cochrane) are systematically searched from 2020-2025, and available studies are further evaluated for eligibility and risk of bias using the Cochrane risk of bias assessment tools for non-randomized studies of interventions (ROBINS-I). Discussion : Six studies were analyzed, with four cohort studies showing no significant association between H2RA use and dementia risk. However, H2RA use was associated with accelerated cognitive decline in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The anticholinergic effects of H2RAs may contribute to cognitive impairment by disrupting histamine's role in the central nervous system and vitamin B12 absorption. However, the pathophysiological mechanisms remain unclear and the findings across studies are inconsistent. Further randomized controlled trials (RCTs) with larger sample sizes are needed to elucidate the potential long-term effects of H2RAs on cognitive health. Conclusion : This systematic review found no clear association between H2RA use and an increased risk of dementia, but noted accelerated cognitive decline in MCI and AD patients. Keywords: alzheimer’s disease; cognitive impairment; dementia; gastric acid-suppressive agents; histamine-2 receptor antagonists
Posterior Ganglion Cyst of the Knee Treated by Ultrasound-Guided Aspiration with Adjunctive Saline Injection: A Case Report Butarbutar, John Christian Parsaoran; Hananto, Joshua Edward; Siahaan, Henoch Gugun Parulian; Yong, Yee Wen
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 15 No. 1 (2026): April 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v15i1.2026.82-86

Abstract

Background: Ganglion cysts around the knee, particularly those originating from the gastrocnemius muscle, are uncommon and may cause significant posterior knee discomfort. Although surgical excision remains the gold standard, it carries risks such as postoperative complications, recurrence, and prolonged recovery.Case Report: A 41-year-old male presented with a 10-year history of posterior knee pain, aggravated during squatting and the Jalsa position during Islamic prayer. Physical examination revealed tenderness in the popliteal fossa without ligamentous instability. Ultrasound (US)-guided aspiration was performed, yielding approximately 4 mL of yellow, viscous fluid, followed by the injection of 10 mL of normal saline to facilitate cyst wall rupture and collapse, without corticosteroid use. This minimally invasive modification may reduce recurrence while avoiding potential steroid-related adverse effects. Immediate improvement in knee mobility was observed. At the 4-month follow-up, complete symptom resolution was reported, and all daily activities, including Islamic prayer, were performed without restriction. Follow-up US imaging confirmed a reduction in cyst size.Discussion: Ganglion cysts can be effectively managed with minimally invasive approaches such as ultrasound-guided aspiration, which offers precise localization and reduced complication risk compared to surgery. In this case, adjunctive saline injection facilitated cyst collapse and resulted in excellent functional recovery, although recurrence remains a possibility.Conclusion: US-guided aspiration with adjunctive saline injection is a promising alternative to surgical excision; however, further studies are needed to confirm its long-term efficacy.
Co-Authors Butarbutar, John Christian Parsaoran Hananto, Joshua Edward Siahaan, Henoch Gugun Parulian Vivien Puspitasari, Vivien