Yong, Yee Wen
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Comprehensive Analysis of Histamine-2 Receptor Antagonists on Dementia Risk: A Systematic Review of Cohort Studies Yong, Yee Wen; Puspitasari, Vivien
Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i02.68

Abstract

Introduction : Histamine-2 Receptor Antagonist (H2RA) are widely used to manage upper gastrointestinal diseases (UGID). However, growing concerns have emerged regarding their potential neurocognitive side effect, particularly an increased dementia risk. H2RAs are often preferred over proton pump inhibitors (PPIs) for enhanced therapeutic efficacy in clinical settings. Material and methods : This research adhered to the PRISMA guidelines to select studies and assess biases. Databases (PubMed, Scopus, and Cochrane) are systematically searched from 2020-2025, and available studies are further evaluated for eligibility and risk of bias using the Cochrane risk of bias assessment tools for non-randomized studies of interventions (ROBINS-I). Discussion : Six studies were analyzed, with four cohort studies showing no significant association between H2RA use and dementia risk. However, H2RA use was associated with accelerated cognitive decline in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The anticholinergic effects of H2RAs may contribute to cognitive impairment by disrupting histamine's role in the central nervous system and vitamin B12 absorption. However, the pathophysiological mechanisms remain unclear and the findings across studies are inconsistent. Further randomized controlled trials (RCTs) with larger sample sizes are needed to elucidate the potential long-term effects of H2RAs on cognitive health. Conclusion : This systematic review found no clear association between H2RA use and an increased risk of dementia, but noted accelerated cognitive decline in MCI and AD patients. Keywords: alzheimer’s disease; cognitive impairment; dementia; gastric acid-suppressive agents; histamine-2 receptor antagonists
Fluctuating Neurological Deficits in Severe Proximal Basilar Artery Stenosis: Conservative Management or Endovascular Angioplasty? Yong, Yee Wen; Puspitasari, Vivien; Suryawijaya, Evlyne Erlyana; Goenawan, Vonny Fibrianty
Acta Neurologica Indonesia Vol. 4 No. 3 (2026): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v4i3.142

Abstract

Introduction : Symptomatic basilar artery (BA) stenosis is a high-risk cause of posterior circulation ischemia with potential for recurrent events despite optimal medical therapy. The decision between conservative treatment and endovascular angioplasty remains challenging, particularly in patients with fluctuating symptoms. Case Report : A 62-year-old man with hypertension, poorly controlled type 2 diabetes mellitus, and prior ischemic stroke presented with a two-month history of oscillopsia, intermittent headache, and transient left-sided weakness. Symptoms progressed to persistent imbalance, diplopia, and gait instability. Brain imaging demonstrated acute infarctions in the left thalamus and right anterior pons, multiple chronic posterior circulation infarcts, occlusion of the right vertebral artery, and severe proximal BA stenosis. Digital subtraction angiography (DSA) confirmed approximately 90% symptomatic proximal BA stenosis with reduced flow to the right anterior inferior cerebellar artery. Despite risk factor control, the patient continued to experience symptoms that significantly interfered with daily activities. Given the high procedural risk, conservative management was chosen with close monitoring. A three-month observation period with repeat DSA was planned to reassess the need for angioplasty. Discussion : This case highlights the unstable course of severe BA stenosis despite medical therapy. Although angioplasty may improve perfusion, BA interventions carry substantial risk due to brainstem perforators, with perforator infarction from “snow-plow” effect during angioplasty being a major concern, particularly in proximal lesions. Conclusion : Severe symptomatic BA stenosis presents a challenging therapeutic dilemma. Short-term observation with planned reassessment may be appropriate, but progressive symptoms require close follow-up and early consideration of endovascular treatment.