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All Journal Jurnal Analis Kesehatan Jurnal Pengabdian Masyarakat Sasambo
Lendawati
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Health Professions Immunology & microbiology

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PEMBERDAYAAN KELOMPOK KADER TB MENINGKATKAN KAPASITAS DIRI DALAM PELAKSANAAN PENGAWASAN MINUM OBAT ANTI TB (OAT) SECARA TERATUR PADA PENDERITA TB PARU FASE LANJUTAN Aminah, Siti; Tuntun, Maria; Lendawati
Jurnal Pengabdian Masyarakat Sasambo Vol. 6 No. 2 (2025): Mei
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jpms.v6i2.1778

Abstract

Pulmonary tuberculosis (TB) is an infectious disease commonly found in India, Indonesia, China, the Philippines, and Pakistan. According to the 2021 global report, Indonesia recorded 824,000 TB cases, but only 393,323 cases (48%) were detected, treated, and reported. In Bandar Lampung, with a population of 1,184,949 in 2021, there were 1,463 suspected TB cases in 2022. The case detection rate (CDR) in Bandar Lampung reached 40%, with a cure rate of 43.2% (1,153 patients). There were 48 deaths during treatment (1.8%). In Panjang District, which consists of eight sub-districts, 187 TB cases were identified, with a cure rate of 38.4%. Based on surveys and information from active TB cadres, poor medication adherence is a major factor in low cure rates. Patients often forget to take their medication or stop taking it once they feel better, increasing the risk of multidrug-resistant TB (MDR-TB). The main challenges include a lack of active TB cadres as treatment supervisors (PMOs), the absence of training programs, and the unavailability of a logbook for monitoring treatment. The proposed solution involves recruiting active TB cadres, providing training, offering guidance, and supplying logbooks. The implementation method includes recruitment interviews, cadre training, and mentoring. Each TB cadre is responsible for five TB patients in the continuation phase of treatment. This community service program's outcome was forming a TB cadre group consisting of 10 PMOs in Panjang District. As a result of the cadres' efforts, 45 TB patients (90%) completed their treatment and were declared cured, 3 patients (6%) continued treatment at a referral hospital, and one patient (2%) passed away. This program highlights the vital role of cadres in improving pulmonary TB recovery rates.
Pengaruh Fraksi Minyak Atsiri Daun Ungu (Graphtophyllum pictum L.) terhadap Apoptosis pada Sel Hela Kanker Serviks Lendawati; Elyanti, Indah
Jurnal Analis Kesehatan Vol. 14 No. 2 (2025): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v14i2.5463

Abstract

Kanker serviks menjadi salah satu penyebab kematian terbanyak ke empat pada perempuan. Global Burden of Cancer Study (GLOBOCAN) tahun 2020 melaporkan kasus baru kanker serviks terdiagnosis sebanyak 604.000, serta kasus terjadinya kematian sebanyak 342.000. Resistensi obat terhadap kemoterapi/radioterapi merupakan tantangan tersendiri untuk menemukan obat dari bahan alam yang memiliki efek samping terkecil sehingga diperlukan penelitian yang lebih mendalam. Daun ungu memiliki toksisitas yang tinggi, pada fraksi etil asetat ditemukan senyawa fenolik, tanin, dan flavonoid yang bisa menjadi alternatif pengobatan. Penelitian ini bertujuan untuk mengetahui pengaruh fraksi minyak atsiri daun ungu (Graphtophyllum pictum L.) terhadap apoptosis pada sel HeLa kanker serviks. Pengujian apoptosis menggunakan metode flow cytometry. Hasil penelitian didapatkan proses apoptosis pada minyak atsiri daun ungu konsentrasi 0,5 LC50 hanya sebesar 11%, sedangkan apoptosis yang terbentuk pada konsentrasi 1 LC50 sebesar 24,7% dan apoptosis tertinggi pada konsentrasi 2 LC50 yaitu sebesar 89%. rata-rata persentase sel yang apoptosis dilakukan uji statistik One Way ANOVA diperoleh nilai p<0,05 sehingga terdapat perbedaan bermakna antara kelompok perlakuan. Uji statistik dilanjutkan dengan uji Post Hoc dan didapatkan nilai p 0,00. Simpulan dalam penelitian ini adalah data LC50 menunjukkan nilai rata-rata LC50 fraksi minyak atsiri daun ungu mampu menginduksi efek apoptosis terhadap sel HeLa kanker serviks.
Co-Authors Elyanti, Indah Maria Tuntun Siti Aminah