Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Nurhafidah, Zahra
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Analysis of the Side Effects of Long-Term Proton Pump Inhibitor (PPI) Use in Patients with Gastroesophageal Reflux Disease (GERD) Nurhafidah, Zahra; Hilmi, Indah Laily; Sudarjat, Hadi
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i2.1628

Abstract

Background: Proton Pump Inhibitors (PPIs) are widely prescribed to manage gastrointestinal disorders, especially gastroesophageal reflux disease (GERD). However, long-term PPI use has been linked to serious side effects and potential complications. Objective: This study aims to analyze the side effects associated with prolonged PPI use in patients with GERD. Methods: A systematic review was conducted using Google Scholar and PubMed databases with relevant keywords. Article selection was carried out carefully based on inclusion and exclusion criteria to ensure the quality and relevance of the data. Additionally, a bibliometric analysis was performed to explore research trends related to the long-term use of PPIs. Results: The review found that prolonged PPI use is associated with various adverse effects, including an increased risk of dementia, progression of chronic kidney disease (CKD), gastric cancer, bone fractures, Frailty Syndrome, hypomagnesemia, iron deficiency, vitamin B12 deficiency, myocardial infarction, and esophageal cancer. The bibliometric analysis also indicated a growing trend of research focusing on the safety and complications of long-term PPI use. Conclusion: Long-term PPI therapy carries significant risks. Therefore, regular monitoring and appropriate discontinuation strategies are essential when using PPIs over extended periods to minimize potential harm.
Co-Authors Indah Laily Hilmi Sudarjat, Hadi