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All Journal Indonesian Journal Health Science and Medicine Journal of Medical Genetics and Clinical Biology (JMGCB)
Al-Safi, Mushtaq Talib
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Cisplatin-induced Genotoxicity and Protective Effect of Aqueous Ginkgo Biloba Extract in an Animal Model: Genotoksisitas yang Diinduksi Cisplatin dan Efek Perlindungan Ekstrak Ginkgo Biloba Berair dalam Model Hewan Al-Safi, Mushtaq Talib
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.145

Abstract

It has recently been proven that many natural compounds made from crude plant extracts offer protection from the passive effects of various contaminants. One common spice and therapeutic herb is Gingko Biloba Extract. To study the effect of aqueous Gingko Biloba Extract in inhibiting the genotoxicity of cisplatin, we gave the first group cisplatin 10mg/kg only. During the work, the second group was treated with an aqueous extract of Gingko Biloba Extract 50mg/kg then 10mg/kg cisplatin. The third group was treated with an aqueous extract of Gingko Biloba Extract 100mg/kg then cisplatin 10mg/kg. On the other hand, the last group was treated with the same aqueous extract 150mg/kg, then 10mg/kg cisplatin. To perform genetic tests, we used micronuclei and sperm abnormality tests. After the treatment with cisplatin, the micronuclei and sperm abnormality were induced; however, the treatment with aqueous extract of Gingko Biloba Extract, the micronuclei and sperm abnormality were significantly reduced in male mice. These results demonstrated that cisplatin treatment alone is not effective as cisplatin treatment in combination with aqueous extract of Gingko Biloba Extract in reducing the amount of sperm head abnormalities and micronucleus. Highlights: Groups: Cisplatin alone; Ginkgo 50, 100, 150 mg/kg + cisplatin. Tests: Micronucleus and sperm abnormality tests performed on male mice. Result: Ginkgo reduced cisplatin-induced micronuclei, sperm abnormalities significantly. Keywords: Crocus sativus, Cisplatin, Sperm head abnormalities, Micronucleus Tests
A STUDY ON THE IMPACT OF TOXOPLASMA GONDII ON THE COMMUNITY VIA GENETIC RESEARCH Al-Safi, Mushtaq Talib
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 12 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i12.1463

Abstract

Objective: Toxoplasma gondii is an obligate intracellular protozoan parasite with a global presence, infecting nearly all warm-blooded animals, including humans, and this research explores the genetic diversity, virulence, and host-pathogen interactions of T. gondii, emphasizing the prevalence and diversity of clonal lineages (Types I, II, III), atypical strains, and single nucleotide polymorphisms (SNPs), particularly in Hungary and Brazil. Method: Comprehensive genomic, proteomic, and transcriptomic methodologies were employed, utilizing advanced genetic tools such as multilocus microsatellite typing, CRISPR-Cas9 editing, and genome sequencing to identify virulence factors, host immune response pathways, and parasite adaptation mechanisms. Result: The study highlights how environmental and host genetic factors shape gene expression and pathogenic outcomes, with key insights from CRISPR-mediated gene disruptions, transcriptional profiling in infected macrophages, comparative genomics between T. gondii and related parasites, and case studies in Wisconsin and Brazil revealing geographic clustering and genotype-specific host outcomes, while efforts in vaccine development target rhoptry and microneme proteins. Novelty: Further, the research addresses ethical, regulatory, and public health dimensions, emphasizing biospecimen collection, community engagement, and global surveillance, contributing to a refined understanding of T. gondii’s biology and broader implications for public health, including standardized virulence evaluation protocols and integrated veterinary and epidemiological strategies.
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