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All Journal Nabatia Indonesian Journal Health Science and Medicine
Kassab, Mohammed Ali
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Agriculture, Biological Sciences & Forestry Health Professions Medicine & Pharmacology Public Health Veterinary

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Applications of Nanotechnology for Combating Drug Resistant Bacterial Infections Using Nanoparticles Kassab, Mohammed Ali
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.155

Abstract

Background: The global rise of antibiotic-resistant bacteria presents a significant threat to public health, necessitating alternative antimicrobial strategies. Specific Background: Nanoparticles such as silver (AgNPs), zinc oxide (ZnO-NPs), and copper oxide (CuO-NPs) have emerged as promising agents due to their broad-spectrum antibacterial properties. Knowledge Gap: However, comparative data on their efficacy across different resistance levels and their underlying mechanisms, particularly oxidative stress induction, remain limited. Aim: This study aims to evaluate the antibacterial efficacy of AgNPs, ZnO-NPs, and CuO-NPs against 150 bacterial isolates categorized into high-, moderate-, and non-resistant bacteria (HRB, MRB, NRB). Results: AgNPs exhibited the highest overall antibacterial activity, with the greatest average zone of inhibition (26.28 mm for MRB) and the lowest MIC/MBC values (7.89 µg/mL for NRB). CuO-NPs produced the highest reactive oxygen species (ROS), suggesting a distinct mechanism of oxidative damage, while ZnO-NPs showed moderate effectiveness. Statistical analyses (ANOVA, Tukey HSD, Pearson’s r) confirmed significant differences among nanoparticles and a strong correlation between ROS generation and bacterial inhibition for CuO-NPs. Novelty: This is among the few studies providing a comprehensive comparison of these nanoparticles across graded resistance levels. Implications: The findings highlight AgNPs' potential in combating resistant bacteria and underscore the need for further research on their long-term safety and integration into antimicrobial therapies.Highlight : AgNPs most effective: Silver nanoparticles showed the highest antibacterial activity across all resistance levels (HRB, MRB, NRB). ROS production matters: CuO-NPs generated the most reactive oxygen species, contributing to bacterial cell damage. Dual mechanisms: Nanoparticles act via oxidative stress and membrane disruption, enhancing their antibacterial potency. Keywords : Nanotechnology, Bacterial Infection, Resistant Bacteria, MRSA
Evaluation of the Biological Activity of some Plant Extracts Against Gram-Positive and Gram-negative Bacteria Hbaiel, Mohammad Kareem; Kassab, Mohammed Ali; Hashim, Abdullah Hijaz
Nabatia Vol 13 No 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/nabatia.v13i2.1657

Abstract

The inhibitory activity of two types of plant extracts, namely the alcoholic and aqueous extracts of Capparis and Artemisia, on the growth of two types of biologically important bacteria included Bacillus cereus, a Gram-positive bacterium, and Pseudomonas aeruginosa, a Gram-negative bacterium, one of the most important opportunistic pathogens.The plant extracts were prepared at different concentrations (10, 20, and 30 mg/ml), and their effect was tested using the diffusion method in the Mueller-Hinton medium. The results showed that the alcoholic extracts were more effective in inhibiting the growth of both bacteria types than the aqueous extracts. The study demonstrated that plant extracts containing active chemical compounds, particularly alcoholic ones, could be used as effective natural antibiotics in healthcare. To pave the way for further comprehensive studies to identify these compounds, their effects, and their potential benefits. These results may contribute to the development of natural therapeutic alternatives to combat bacterial infections or be used to indicate the effectiveness of active chemical compounds present in plants by inhibiting B. cereus.
Co-Authors Hashim, Abdullah Hijaz Hbaiel, Mohammad Kareem