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Primawati, Junia Salsha
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Antioxidant and Cytotoxic Potential of Ethyl Acetate Fraction of Gandaria Stem Bark (Bouea macrophylla) Against MCF-7 Cell Line Situmeang, Boima; Primawati, Junia Salsha; Oktafiani, Ismi; Musa, Weny JA; Kilo, Ahmad Kadir
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.345-349

Abstract

The stem bark of Bouea macrophylla (gandaria) represents a promising subject for further scientific investigation. Previous studies have reported that the bark contains high concentrations of total phenolic and flavonoid compounds, associated with potent antioxidant activity. This study evaluates the antioxidant and cytotoxic potential of the ethyl acetate fraction of B. macrophylla stem bark. Antioxidant activity was assessed using the DPPH and ABTS radical scavenging methods, while cytotoxic activity against MCF-7 breast cancer cells was determined using the MTT assay. The ethyl acetate fraction exhibited strong antioxidant activity with IC₅₀ values of 5.837 ± 0.060 ppm (DPPH) and 9.645 ± 0.697 ppm (ABTS). The cytotoxicity assay revealed an IC₅₀ value of 99.55 ppm, indicating moderate cytotoxic potential. These findings suggest that the ethyl acetate fraction of B. macrophylla stem bark possesses significant antioxidant activity and potential anticancer properties, supporting its possible application in natural therapeutic development.
LC-MS Analysis of Ethyl Acetate Fraction of Gandaria (Bouea macrophylla Griff.) Stem Bark and Molecular Docking Study against HER2 Protein Primawati, Junia Salsha; Sriwijayanti, Sriwijayanti; Situmeang, Boima; Safuroh, Siti; Agustin, Yuke
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.91-95

Abstract

Breast cancer is a disease that has long been a source of concern for the public due to its high mortality rate. Excessive exposure to free radicals has been identified as a potential carcinogen, thus necessitating the utilization of antioxidants to counteract the damaging effects of these molecules. Gandaria (Bouea macrophylla Griff.) is a plant that is commonly found in Java, Sumatra, Maluku, and Kalimantan. B. macrophylla is known to have strong antioxidant activity, which is correlated with anticancer activity. A part of B. macrophylla that has not been extensively researched is its stem bark. The objective of this study was to analyze the potential of the ethyl acetate fraction of B. macrophylla stem bark as an anticancer agent using in silico method. The ethyl acetate fraction of B. macrophylla stem bark was characterized by LC-MS, which revealed four major compounds: 4-hydroxy-3-(3-oxo-1-phenylbutyl)-chromen-2-one, 1-(2,5-dihydroxyphenyl)-propan-1-one, 3-ethoxy-4-hydroxybenzaldehyde, and 2-nitrobenzoic acid. Molecular docking was performed between the compounds against the HER2 protein with PDB ID 3RCD. The four compounds demonstrated binding energy values of -8.29 kcal/mol, -5.04 kcal/mol, -4.66 kcal/mol, and -4.28 kcal/mol, respectively.
Co-Authors Ahmad Kadir Kilo Boima Ramses Situmeang Oktafiani, Ismi Safuroh, Siti Situmeang, Boima Sriwijayanti, Sriwijayanti Yuke Agustin