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What is the comparative effectiveness of cognitive behavioral therapy versus medical treatment in improving sexual function for women with sexual dysfunction? Yunike Putri Nurfauzia; I Made Adi Saputra Wijaya; Mutia Juliana; Yahya Nurlianto
The International Journal of Medical Science and Health Research Vol. 12 No. 3 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/sndsqr62

Abstract

Introduction: This review investigates the comparative effectiveness of Cognitive Behavioral Therapy (CBT) versus medical treatments in improving sexual function among adult women diagnosed with sexual dysfunction. Sexual dysfunctions studied include provoked vestibulodynia (PVD), hypoactive sexual desire disorder (HSDD), vaginismus, and related conditions. Methods: Fifteen studies, primarily randomized clinical trials, were analyzed. Interventions included various forms of CBT (couple-based, group-based, mindfulness-based) and medical treatments such as lidocaine, sildenafil, bupropion, and topical steroids. Outcomes measured were sexual function, pain, sexual satisfaction, psychological distress, and relational factors. Results: CBT consistently showed significant improvements in sexual function, psychological well-being, and relationship satisfaction. For example, one study reported a 66% improvement in sexual performance after 12 weeks of CBT, and another showed an 18-point increase in sexual function scores at six months follow-up. Medical treatments provided rapid relief of physiological symptoms like pain and lubrication deficits, with effect sizes sometimes comparable to CBT. However, CBT was more effective in addressing psychological and relational aspects. Discussion: CBT’s holistic approach addresses both physiological and psychological factors, offering longer-lasting benefits and skill development for patients. Medical treatments are advantageous for quick symptom relief and ease of administration. Combined approaches may optimize outcomes. Conclusion: Both CBT and medical treatments are effective, but CBT offers broader and potentially more durable improvements in sexual health. Treatment choice should be individualized based on patient needs and dysfunction type.
What is The Association Between Low Serum Vitamin A Levels and The Risk of Developing Gestational Trophoblastic Disease Yunike Putri Nurfauzia; I Made Adi Saputra Wijaya; Mutia Juliana; Yahya Nurlianto
The International Journal of Medical Science and Health Research Vol. 12 No. 3 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/cbg2nb15

Abstract

Introduction: Gestational Trophoblastic Disease (GTD) comprises a group of disorders characterized by abnormal trophoblastic proliferation, including hydatidiform mole and gestational trophoblastic neoplasia (GTN). Vitamin A, known for its role in cellular differentiation and immune modulation, has been studied for its potential association with GTD risk and treatment outcomes. Methods: A systematic review of recent studies was conducted, focusing on serum vitamin A levels in GTD patients and the effects of vitamin A supplementation on treatment response. Included studies ranged from cross-sectional analyses to randomized controlled trials involving human subjects diagnosed with various GTD subtypes. Results: Ferraz et al. (2020) reported normal serum vitamin A levels (0.3–0.7 mg/dL) in patients with complete hydatidiform mole, indicating no association between low vitamin A levels and GTD risk. Conversely, Hidayat et al. (2020) demonstrated that vitamin A supplementation (6,000 IU/day) combined with methotrexate chemotherapy in low-risk GTN patients led to a more rapid decline in beta-human chorionic gonadotropin (β-hCG) levels and reduced chemotherapy resistance compared to chemotherapy alone. Discussion: While low serum vitamin A does not appear to predispose to GTD, supplementation may enhance chemotherapy efficacy, possibly through antioxidant and immunomodulatory mechanisms. However, limited sample sizes and study heterogeneity warrant further research. Conclusion: Vitamin A supplementation shows promise as an adjunct therapy in GTD treatment, improving outcomes in select patients, though it is not linked to disease risk. Larger, controlled studies are needed to confirm these findings