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All Journal Borneo Journal Of Pharmascientech Jurnal Konstruksi dan Infrastruktur : Teknik Sipil dan Perencanaan SmartComp
Febriyadi, Febriyadi
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Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Electrical & Electronics Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Transportation

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Potensi Tanaman Endemik Sulawesi Tengah Etlingera Tjiasmantoi Sebagai Kandidat Obat Antituberkulosis Baru: Studi In Silico Dan In Vitro Azzahra, Zahwa; Amalia , Nurul Izza; Nursagita, Zhafirah Tri; Febriyadi, Febriyadi; Wardhani, Shara; Ihwan, Ihwan; Jamaluddin, Jamaluddin
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.646

Abstract

Plants of the Zingiberaceae family have a lot of potential as medicinal raw materials, especially the Etlingera genus which has antimicrobial activity. It is suspected that secondary metabolite compounds in the Etlingera genus play an important role in antimicrobial activity by activating STAT that affects the production of cytokines and chemokines that are important in fighting Mycobacterium tuberculosis bacteria, as is the case with the newly discovered Etlingera tjiasmantoi species as an endemic plant that is empirically used as an anticancer. This research was conducted to determine the potential of ethanol extract of Etlingera tjiasmantoi leaves as an antituberculosis in silico and in vitro. The research method went through two stages, namely in silico with the stages of network pharmacology test, molecular docking, and prediction of Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) of compounds and in vitro to validate the results of in silico testing using the Resazurin Microtiter Assay (REMA) method. The results of in silico analysis showed that the Etlingera tjiasmantoi plant has a 2-Methyldecalin compound with a binding energy of -6.2 which is smaller than the isoniazid control ligand so that it has a strong bond with the JAK2 target protein and a good ADMET profile orally, in vitro tests showed that concentrations of 500 ppm and 750 ppm were able to fight Mycobacterium tuberculosis bacteria so that the ethanol extract of Etlingera tjiasmantoi leaves has the potential as a new antituberculosis drug candidate.
Analisis Penerapan Sistem Informasi Pemeliharaan Jalan Berbasis Web Pada Jalan Kabupaten Studi Kasus Jalan Kabupaten Ogan Ilir Febriyadi, Febriyadi; Agustine, Melawati; Kadarsa, Edi
Smart Comp :Jurnalnya Orang Pintar Komputer Vol 12, No 1 (2023): Smart Comp: Jurnalnya Orang Pintar Komputer
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/smartcomp.v12i1.4593

Abstract

Pemeliharaan jalan yang dilakukan oleh Penyelenggara lalan khususnya pada jalan Kabupaten Ogan Ilir wajib memenuhi ketentuan yang telah diamanatkan pada PERMEN PU no.13, sehingga Dinas PUBM Ogan Ilir wajib memiliki suatu sistem infromasi pemeliharaan jalan dan rencana pemeliharaan jalan.Pada tahun 2020 Tingkat kemantapan jalan pada jalan Kabupaten Ogan Ilir adalah 55% dan masih dibawah target SPM jalan kabupaten yaitu 60%. Untuk meningkatkan nilai kemantapan jalan dan menentukan rencana prioritas pemeliharaan jalan maka perlu dibuat suatu sistem informasi yang dapat selalu up to date dan mudah untuk diakses. Penelitian ini bertujuan menganalisis Penerapan sistem informasi pemeliharaan jalan di Kabupaten Ogan Ilir Provinsi Sumatera Selatan. Beberapa metode yang digunakan dalam penelitian ini yaitu metode survey nilai IRI dengan menggunakan aplikasi android Roadbump Pro dan metode analisis deskriftif dalam melakukan pengelolaan data. Melakukan pemetaan dan digitasi dengan mengunakan GIS dan melakukan penyusunan sistem Informasi Pemeliharan jalan berbasis WEB dengan Bahasa  pemrograman HTML, CSS dan java script. Hasil penelitian sistem informasi didapatkan nilai kematapan jalan kabuaten Ogan Ilir pada tahun 2021 yaitu 56% masih dibawah SPM minimum jalan yaitu 60%. Peta jaringan jalan yang memiliki nilai kemantapan jalan dengan QGIS dan prioritas pemeliharaan jalan berdasarkan nilai kemantapan jalan. WEB sistem informasi pemeliharaan jalan yang berisi database Profil Ogan Ilir, data inventaris jalan Kabupaten Ogan Ilir, Peta jaringan jalan yang memiliki nilai kemantapan jalan dan Prioritas pemeliharaan jalan. Manfaat penelitian ini  menjadi tolak ukur dan pertimbangan instasi pengelola pemeliharaan jaringan Kabupaten Ogan Ilir dan dinas terkait lainnya dalam meningkatkan nilai kemantapan jalan dan menentukan prioritas pemeliharaan jalan pada jalan Kabupaten Ogan Ilir.
Analisis Dampak Mud Pumping Terhadap Kerusakan Sleeper Pada Jalur Kereta Api Tanjung Karang – Rejosari (Studi Kasus Divre IV Tanjung Karang) Arif, Muhammad Rizki; Siantar, Roy Jones Lumban; Febriyadi, Febriyadi; Setyaji, Arif; Sari, Nurwanda; Mardhotillah, Nur Annisa; Aini, Nur Syahidah; Jori, Rahmatika Dwi Putri
Jurnal Konstruksi dan Infrastruktur : Teknik Sipil dan Perencanaan Vol 14 No 1 (2026): Jurnal Konstruksi dan Infrastruktur Vol 14 No.1 : April 2026
Publisher : Civil Engineering Department, Faculty of Engineering, Universitas Swadaya Gunung Jati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/jki.v14i1.11977

Abstract

This study analyzes the impact of mud pumping on track stability and damage to K-550-type monoblock concrete sleepers on the Tanjung Karang–Rejosari line (DIVRE IV Tanjung Karang). This Class I track, with a gauge of 1,067 mm, carries an annual load of 82,883.21 tons. Mud pumping causes water mixed with mud to rise to the surface of the ballast, which disrupts load distribution and the stability of the track structure. The research methodology comprises four main stages: (1) field observations at four critical locations (Km 13+8/9, Km 14+2/3, Km 25+2/3, and Km 28+5/6); (2) measurements using a Dynamic Cone Penetrometer (DCP) and a densometer to obtain RC, CBR, and Evd parameters; (3) track geometry evaluation to detect elevation deviations; and (4) technical analysis of sleepers based on an elastic modulus of 150,093.30 kg/cm² and a permissible stress of 210 kg/cm². The research results indicate that the most critical condition is at Km 25+2/3, with an RC value of 14.37 kN/m, a CBR of 3.85%, and an Evd of 41.6 MN/m². Overall, several segments have CBR values below the safe threshold (15–24%), indicating a significant decrease in ballast density due to mud pumping. Technical analysis confirms that mud accumulation disrupts the distribution of effective stress and accelerates sleeper deterioration. As a mitigation measure, it is recommended to install woven geotextile, replace the ballast material, and implement periodic monitoring using DCP/densometer instruments to maintain track stability within acceptable limits and extend the service life of the railway infrastructure.
Co-Authors Agustine, Melawati Amalia , Nurul Izza Arif, Muhammad Rizki Azzahra, Zahwa Edi Kadarsa, Edi Jamaluddin Jamaluddin Jori, Rahmatika Dwi Putri Mardhotillah, Nur Annisa nur syahidah aini Nursagita, Zhafirah Tri Sari, Nurwanda Sembiring, Rinawati Setyaji, Arif Siantar, Roy Jones Lumban Wardhani, Shara