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All Journal Althea Medical Journal Jurnal Health Sains Jurnal Impresi Indonesia Eduvest - Journal of Universal Studies
Fikriyah, Lathifatul
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Correlation Between MMSE Scores and NIHSS In Acute Stroke Infarct Patients Fikriyah, Lathifatul
Jurnal Impresi Indonesia Vol. 4 No. 5 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i5.6531

Abstract

Stroke is defined as an episode of neurological dysfunction resulting from focal infarction of the brain, spinal cord, or retina, confirmed by pathological findings, imaging, or other objective evidence of ischemia within a specific vascular territory. Alternatively, stroke may be diagnosed based on the presence of clinical symptoms persisting for ?24 hours or resulting in death, provided other potential causes have been excluded. Stroke patients may experience cognitive, sensory, and motor dysfunction as a result of brain cell damage, which can affect their ability to communicate and carry out daily tasks. Objective: To ascertain the correlation between acute infarction stroke patients' cognitive performance and stroke severity at Dr. Sutomo Surabaya Hospital Methods: An analytical observational cross-sectional design was used in this investigation. Patients diagnosed with acute ischemic stroke who were admitted to Dr. Soetomo Surabaya Hospital between February and May 2023 and who satisfied the inclusion and exclusion criteria made up the study population. A consecutive admission strategy was used for sampling. Serum lactate dehydrogenase (LDH) levels and the National Institutes of Health Stroke Scale (NIHSS) score were evaluated upon admission. Results: The study included 30 patients in all, 14 (46.7%) female and 16 (53.3%) male. There is a correlation between MMSE and NIHSS, according to statistical tests that deem these results significant. The table's results for the correlation test between MMSE and NIHSS Score using the Pearson test show that the p-value is 0.000, where the value is < 0.05. The correlation test's r value is 0.905, meaning that the degree of association between the MMSE score variable and NIHSS is 0.905, or 90.5%, and that the value falls into the strong relationship strength category. The MMSE and NIHSS scores have a negative association; a high or big MMSE score will result in a low NIHSS score, and vice versa. Conclusion: There is a strong negative correlation between MMSE score and functional level assessed by NIHSS in patients with acute ischemic stroke, and statistically significant.
Correlation Between Lactate Dehydrogenase (LDH) Values and Aspects Score at the Beginning of Treatment in Acute Ischemic Stroke Fikriyah, Lathifatul
Jurnal Health Sains Vol. 6 No. 7 (2025): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v6i7.2656

Abstract

Stroke is the second leading cause of death worldwide, with ischemic stroke comprising 87% of cases. Metabolic acidosis from hypoxia promotes anaerobic glycolysis, raising lactate dehydrogenase (LDH) levels, which reflects neuronal tissue injury and inflammation in acute ischemic stroke. The Alberta Stroke Program Early CT Score (ASPECTS) is used to assess ischemic brain injury on non-contrast CT, aiding early prognosis and treatment decisions. This cross-sectional study at Dr. Soetomo Hospital, Surabaya (February–May 2023), included 30 acute ischemic stroke patients (53.3% male, mean age 60.2 ± 7.1 years, onset 2–5 days). Exclusion criteria were prior thrombolysis, cancer, or organ failure. LDH levels were measured at admission using the Alinity C analyzer, and ASPECTS was calculated from initial CT scans. Spearman’s correlation was used for analysis. Results showed a significant inverse correlation between LDH and ASPECTS (r = -0.279, p = 0.003), indicating that higher LDH levels correspond with lower ASPECTS (larger infarcts). Mean LDH was elevated (258.75 ± 50.65 U/L, normal 120–190 U/L). Comorbidities included hypertension (90%), dyslipidemia (83.3%), and diabetes mellitus (56.7%). These findings suggest that serum LDH may be a valuable adjunct biomarker for early assessment of ischemic stroke severity when advanced imaging is unavailable, helping clinicians estimate infarct size rapidly. Further research involving larger populations is recommended to confirm LDH’s utility and to examine its combination with other biomarkers for acute ischemic stroke management.
Correlation Between Lactate Dehydrogenase (LDH) Values and Aspects Score at the Beginning of Treatment in Acute Ischemic Stroke Fikriyah, Lathifatul; Ardhi, M. Saiful; Setyowatie, Sita
Eduvest - Journal of Universal Studies Vol. 5 No. 12 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i12.51911

Abstract

On a global scale, stroke ranks as the second biggest killer and the third most prevalent cause of disability. Metabolic acidosis occurs when oxygen is not present in the blood after an ischemic stroke. The purpose of this research was to show that acute ischemic stroke patients treated at Surabaya's Dr. Soetomo General Hospital had an association between their lactate dehydrogenase (LDH) serum level and their ASPECTS score before treatment began. Sampling was conducted using consecutive admissions methods. The ASPECTS score and LDH serum examination were assessed and taken upon admission. Thirty individuals were enrolled in the trial; sixteen (53.3%) were male and fourteen (46.7%) were female. The results demonstrate a relationship or correlation between LDH and ASPECT Score according to the Spearman test. The p-value is 0.003, which is less than 0.05, indicating a meaningful relationship or correlation between LDH and ASPECTS Score based on statistical tests. The r-value of -0.279 indicates a weak inverse relationship (27.9% strength) between the ASPECT score variable and LDH, according to the results of the correlation test. The relationship between LDH and ASPECT Score is negative, where if the ASPECT score value is high, the LDH value will be low, and vice versa. In conclusion, this study demonstrates a statistically significant (p = 0.003) but weak inverse correlation (r = -0.279) between serum LDH levels and ASPECT scores in acute ischemic stroke patients.
Correlation Between Lactate Dehydrogenase Levels and National Institutes of Health Stroke Scale Scores at the Onset of Acute Ischemic Stroke Fikriyah, Lathifatul; Ardhi, Mohammad Saiful; Setyowatie, Sita
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4391

Abstract

Background: In acute ischemic stroke, reduced oxygen supply may trigger metabolic acidosis and cellular injury. Lactate dehydrogenase (LDH), as an intracellular enzyme, helps generate energy by converting pyruvate to lactate in glycolysis. This study aimed to examine the correlation between serum LDH levels and the National Institutes of Health Stroke Scale (NIHSS) score at the onset of treatment among patients with acute ischemic stroke.Methods: This analytical observational study used cross-sectional design, involving patients with acute ischemic stroke hospitalized at Dr. Soetomo Surabaya Hospital, Indonesia, between February and May 2023. Participants were selected using consecutive sampling. Serum LDH levels and NIHSS score were measured upon admission. The correlation between LDH levels and NIHSS score was analyzed using the Spearman test, with statistical significance set at p<0.05. Results: A total of 30 patients were included, of whom 16 (53.3%) were male. A significant correlation was found between LDH levels and NIHSS scores (p=0.001). The correlation coefficient (r=0.785) indicated a strong positive correlation between serum LDH levels and stroke severity.Conclusions: This study demonstrates a strong positive correlation between LDH levels and NIHSS scores at the onset of acute ischemic stroke treatment. These findings suggest that LDH may serve as a practical early biomarker for assessing stroke severity. Integrating LDH measurement into initial evaluation may facilitate faster risk stratification and support timely clinical decision-making. Further studies with larger sample sizes are needed to validate its prognostic role in routine practice.
Co-Authors Ardhi, M. Saiful Ardhi, Mohammad Saiful Sita Setyowatie