Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Althea Medical Journal Jurnal Health Sains Cermin Dunia Kedokteran
Fikriyah, Lathifatul
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Correlation Between Lactate Dehydrogenase (LDH) Values and Aspects Score at the Beginning of Treatment in Acute Ischemic Stroke Fikriyah, Lathifatul
Jurnal Health Sains Vol. 6 No. 7 (2025): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v6i7.2656

Abstract

Stroke is the second leading cause of death worldwide, with ischemic stroke comprising 87% of cases. Metabolic acidosis from hypoxia promotes anaerobic glycolysis, raising lactate dehydrogenase (LDH) levels, which reflects neuronal tissue injury and inflammation in acute ischemic stroke. The Alberta Stroke Program Early CT Score (ASPECTS) is used to assess ischemic brain injury on non-contrast CT, aiding early prognosis and treatment decisions. This cross-sectional study at Dr. Soetomo Hospital, Surabaya (February–May 2023), included 30 acute ischemic stroke patients (53.3% male, mean age 60.2 ± 7.1 years, onset 2–5 days). Exclusion criteria were prior thrombolysis, cancer, or organ failure. LDH levels were measured at admission using the Alinity C analyzer, and ASPECTS was calculated from initial CT scans. Spearman’s correlation was used for analysis. Results showed a significant inverse correlation between LDH and ASPECTS (r = -0.279, p = 0.003), indicating that higher LDH levels correspond with lower ASPECTS (larger infarcts). Mean LDH was elevated (258.75 ± 50.65 U/L, normal 120–190 U/L). Comorbidities included hypertension (90%), dyslipidemia (83.3%), and diabetes mellitus (56.7%). These findings suggest that serum LDH may be a valuable adjunct biomarker for early assessment of ischemic stroke severity when advanced imaging is unavailable, helping clinicians estimate infarct size rapidly. Further research involving larger populations is recommended to confirm LDH’s utility and to examine its combination with other biomarkers for acute ischemic stroke management.
Correlation Between Lactate Dehydrogenase Levels and National Institutes of Health Stroke Scale Scores at the Onset of Acute Ischemic Stroke Fikriyah, Lathifatul; Ardhi, Mohammad Saiful; Setyowatie, Sita
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4391

Abstract

Background: In acute ischemic stroke, reduced oxygen supply may trigger metabolic acidosis and cellular injury. Lactate dehydrogenase (LDH), as an intracellular enzyme, helps generate energy by converting pyruvate to lactate in glycolysis. This study aimed to examine the correlation between serum LDH levels and the National Institutes of Health Stroke Scale (NIHSS) score at the onset of treatment among patients with acute ischemic stroke.Methods: This analytical observational study used cross-sectional design, involving patients with acute ischemic stroke hospitalized at Dr. Soetomo Surabaya Hospital, Indonesia, between February and May 2023. Participants were selected using consecutive sampling. Serum LDH levels and NIHSS score were measured upon admission. The correlation between LDH levels and NIHSS score was analyzed using the Spearman test, with statistical significance set at p<0.05. Results: A total of 30 patients were included, of whom 16 (53.3%) were male. A significant correlation was found between LDH levels and NIHSS scores (p=0.001). The correlation coefficient (r=0.785) indicated a strong positive correlation between serum LDH levels and stroke severity.Conclusions: This study demonstrates a strong positive correlation between LDH levels and NIHSS scores at the onset of acute ischemic stroke treatment. These findings suggest that LDH may serve as a practical early biomarker for assessing stroke severity. Integrating LDH measurement into initial evaluation may facilitate faster risk stratification and support timely clinical decision-making. Further studies with larger sample sizes are needed to validate its prognostic role in routine practice.
Dolikoektasia Serebral Multipel sebagai Faktor Potensial Penyebab Perdarahan Intrakranial dan Intraventrikular Selama Krisis Hipertensi: Laporan Kasus: Laporan Kasus Basja, Agnes Triana; Fikriyah, Lathifatul
Cermin Dunia Kedokteran Vol 53 No 06 (2026): Juni 2026
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i06.1899

Abstract

Introduction: Dolichoectasia (DE) represents an uncommon vascular anomaly of the brain, characterized by abnormal dilation and elongation of cerebral blood vessels. Its occurrence is relatively rare, with an estimated prevalence ranging from 0.05% to 0.06%. Although predominantly observed within the vertebrobasilar system, cases involving the anterior cerebral circulation have also been documented. Patients with DE are susceptible to intracranial and intraventricular hemorrhage. Case: A 54-year-old male with sudden extremity weakness, hypertensive crisis, and hyperlipidemia. CT imaging showed intracranial hemorrhage in the left thalamic and intraventricular hemorrhage in the posterior horn of the left ventricle with enlargement and tortuosity of the intracerebral artery and vertebrobasilar artery. These imaging findings led to a diagnosis of multiple cerebral dolichoectasia. The patient underwent conservative management with antihypertension and decompression therapy, leading to a gradual alleviation of symptoms. Discussion: Hypertension is considered the major risk factor for intracranial hemorrhage in this patient, while dolichoectasia may represent an associated vascular abnormality that potentially increases vessel wall vulnerability. Structural alterations in dolichoectatic vessels, including disruption of elastic fibers and remodeling of the tunica media, may contribute to reduced vascular integrity under severe hemodynamic stress. The coexistence of hypertensive crisis and multiple dolichoectasia may therefore increase susceptibility to hemorrhagic complications. Conclusion: CT imaging is essential for the diagnosis of dolichoectasia and the detection of associated complications, including intracranial and intraventricular hemorrhage. Early and accurate diagnosis may improve patient outcomes by enabling appropriate therapy.
Co-Authors Ardhi, Mohammad Saiful Basja, Agnes Triana Sita Setyowatie