Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Novalina, Fellen
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
PENGARUH SUPLEMENTASI SINBIOTIK TERHADAP PROFIL GLIKEMIK DAN LIPID PADA PASIEN DIABETES MELITUS TIPE 2: Sebuah Tinjauan Sistematis pada Studi Randomisasi Acak Ansyori, Achmad Rifky; Zefianto, Zefianto; Riena, Nadya Ratna; Novalina, Fellen
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 11.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i2.771

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a glucose homeostasis disorder characterized by chronic hyperglycemia caused by insulin resistance. It is believed that this condition is associated with intestinal bacteria dysbiosis that potentially worsens T2DM progressivity. A number of experimental studies have recommended synbiotic supplementation, based on the principle of intestinal microbe regulation, as nutrition therapy for T2DM. This systematic review evaluates the effect of synbiotic supplement on T2DM patients’ glycemic and lipid profile. Methods: Articles published from 2014 to 2021 were searched with a number of search engines: PubMed, ResearchGate, Google Scholar, and Elsevier. This systematic review aims to evaluate the effect of synbiotic supplement on T2DM patients’ glycemic and lipid profile. Discussion: Eighty randomized control trials (RCTs) met the inclusion criteria to be analyzed qualitatively in this systematic review. The quality of each included study was evaluated with Cochrane’s Risk of Bias (ROB-2). Overall, in comparison to the control (placebo) group, the intervention group that received synbiotic supplementation showed a more significant decrease in fasting glycemic and HbA1c level. T2DM patients also appeared to experience improvement in lipid profile (decrease in cholesterol, triglyceride, and low density lipoprotein cholesterol (LDL-C), along with increase in high density lipoprotein cholesterol (HDL-C)) after receiving synbiotic supplementation. In addition, synbiotic supplementation is evaluated as safe to be consumed by T2DM patients with minimal side effects. Conclusion: The available evidence demonstrates the potential use of synbiotic supplementation as a nutrition therapy for T2DM treatment. Keywords: glycemic profile, lipid profile, synbiotic, type 2 diabetes mellitus.
Exploring the Role of Mitochondria in Alzheimer with Network Pharmacology: A Bioinformatics Analysis Riena, Nadya Ratna; Novalina, Fellen; Heng, Kahtleen Riani
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Book of Abstrack RCIMS 2025
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.vi.950

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disease marked by the pathological accumulation of beta-amyloid peptide and hyperphosphorylated tau. Growing body of evidence indicates that mitochondrial dysfunction plays a pivotal role in AD pathogenesis, by inducing neurotoxicity through the formation of oxidative stress and reactive oxygen species (ROS). This study aims to investigate relevant mitochondrial proteins in Alzheimer by employing network pharmacology. Protein-coding genes associated with AD were identified from the GeneCards database, extracting only genes scoring >1 in relevancy. Datasets associated with mitochondria were extracted from the STRING database. 621 overlapping proteins from both keywords were further enriched and topologically analyzed. This study employed enrichment analyses using ShinyGO to identify relevant biological, cellular, and molecular processes, in addition to disease pathways. Topology analyses were conducted through STRING and Cytoscape by implementing eight different centrality parameters and clustering, the genes were further curated to obtain pivotal proteins in AD and their dysregulation. Aligned with our enrichment analyses, the proteins topologically relevant were components of the mitochondrial oxidative phosphorylation (OXPHOS) pathway, crucial to the respiratory electron transport chain and ATP synthesis system. This study provides a foundation for the discovery of multi-target drugs in AD therapy.
Co-Authors Ansyori, Achmad Rifky Heng, Kahtleen Riani Riena, Nadya Ratna Zefianto, Zefianto