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All Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Ali Noory Fajer
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Health Professions Nursing Public Health

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An Investigation into the Antioxidant Effects of Frankincense Aqueous Extract and its Influence on Acetyl Cholinesterase in Alzheimer's patients in Diwaniyah Meaad Nasser Hussein; Shaimaa Adnan; Ali Noory Fajer
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1494

Abstract

The present study aims to prepare the aqueous extract of the frankincense plant and then identify the most important biologically active substances in it, and study the effect of these substances against free radicals (2,2-diphenylpicrylhydrazyl (DPPH)) and Total Antioxidant Capacity. Then the effect of extract was tested on the blood serum of Alzheimer's patients in the nursing home in Diwaniyah Governorate, where 30 people were taken. 10 of them were healthy and were considered a positive control groupG1, and 20 of them were Alzheimer's patients, where 10 of them were considered a negative control groupG2, and the other 10 Alzheimer's patients had their serum treated with the extract of frankincenseG3. The effect of the extract on malondialdehyde and acetylcholinesterase enzyme was tested. The current study showed that extract contains biologically active substances such as (Flavonoids, Phenols, Tannins Triterpenoids, Steroids and Saponins) and these substances had an effective effect in inhibiting the radical (DPPH) where the inhibition rate reached 88% at (250mg/ml) and Total Antioxidant Capacity was (8.8*103 µmol/L) at the same concentration. That results also showed the significant rise in the concentration malonaldehyde in Alzheimer’s patients (G2, G3) when compared with G1. When the G3 was treated with the aqueous extract, a decrease in the concentration of malonaldehyde (3.23µml/l) was observed. The significant reduction in the Activity of the Acetylcholinesterase enzyme (3.97U/ml) was also observed in the (G3) as compared with(G2) (12.297U/ml). This is due to the biologically active substances in the extract, which indicates the possibility of using this extract to treat Alzheimer's patients in the future.
Evaluation Antioxidant and Immunity Activities of Green Synthesized Selenium Nanoparticles by Extraction spirulina to reduces oxidative stress induced by phentermine in males rats Hawraa Ali Sultan; Ali Noory Fajer
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1543

Abstract

Abstract. Background: Slimming drugs, such as phentermine, are widely used for weight reduction but are known to induce oxidative stress, particularly affecting hepatic and renal tissues. Selenium nanoparticles (SeNPs), especially those biosynthesized using natural sources like spirulina platensis, have demonstrated promising antioxidant and protective activities in biological systems. Objective: This study aimed to assess the protective effects of selenium nanoparticles synthesized from spirulina platensis extract on renal and hepatic functions in male rats exposed to phentermine induced oxidative stress. Methods: Twenty-six adult male wistar rats were divided into five experimental groups: control group (dosed with water n=5), SeNPs group (dosed with SeNPs n=5), phentermine group (dosed with phentermine n=5), SeNPs then phentermine group (dosed with SeNPs then phentermine n=5), phentermine then SeNPs group (dosed with phentermine then SeNPs n=5). The experiment lasted for 45 days, the measurement of cytokines IL-6, IL-12, TOS and TO-AC. Results: Phentermine administration significantly increased cytokines IL-6, IL-12 indicating marked oxidative stress and immune activation. Treatment with SeNPs alone or in combination with phentermine notably improved these parameters. The group dosed with SeNPs prior to phentermine (SeNPs then phentermine) showed the most prominent protective effects with values approaching those of the control. Conclusions: Selenium nanoparticles from spirulina platensis demonstrated significant protective, antioxidant, and immunomodulatory effects against phentermine induced immune disturbances. These findings support their potential
Co-Authors Hawraa Ali Sultan Meaad Nasser Hussein Shaimaa Adnan