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Prima Della Fegita
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HUBUNGAN JUMLAH LEUKOSIT DENGAN LAMA KETUBAN PECAH DINI PADA IBU HAMIL DI RUMAH SAKIT ISLAM SITI RAHMAH PADANG TAHUN 2021-2023 Prima Della Fegita; Rahmi Syukra Fadilla
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1437

Abstract

Premature Rupture of Membranes (PROM) can occur spontaneously at a gestational age >37 weeks, referred to as term PROM, and at ≤37 weeks, referred to as preterm PROM. This condition is a serious obstetric problem that can lead to maternal and neonatal infections and complications such as prematurity, morbidity, and mortality. PROM may arise due to infection, marked by leukocytosis. Leukocytosis can be evaluated through blood tests, which are used to monitor the potential for infections during pregnancy. This study aims to investigate the relationship between leukocyte count and the duration of PROM in pregnant women at Siti Rahmah Islamic Hospital, Padang, during 2021–2023. This research employed an analytical observational method with a cross-sectional design, involving simultaneous data collection of variables. The sample size for this study was 99 participants. Statistical analysis using the Kolmogorov-Smirnov test yielded a p-value of 1.000 > 0.05. This indicates that there is no relationship between leukocyte count and the duration of PROM in pregnant women at Siti Rahmah Islamic Hospital, Padang, from 2021 to 2023. There is no significant relationship between leukocyte count and the duration of PROM in pregnant women at Siti Rahmah Islamic Hospital, Padang, during 2021–2023.
RECURRENT PREGNANCY LOSS IN A PREGNANT WOMAN WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A CASE REPORT AND LITERATURE REVIEW Prima Della Fegita
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1795

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominantly affects women of reproductive age and poses significant risks during pregnancy. Pregnant women with SLE have a higher incidence of maternal and fetal complications, including recurrent pregnancy loss, preterm birth, and fetal growth restriction. Early recognition and multidisciplinary management are essential to improve pregnancy outcomes. We report a case of a 31-year-old pregnant woman (G4P0A3) at 19–20 weeks of gestation who presented with progressive joint pain, thrombocytopenia, alopecia, and photosensitive facial rash. The patient had a history of three previous pregnancy losses. Immunological examination revealed positive anti–double-stranded DNA antibodies, confirming the diagnosis of systemic lupus erythematosus with mild disease activity. Obstetric ultrasound showed a single live intrauterine fetus consistent with gestational age. The patient was managed collaboratively by obstetrics–gynecology and internal medicine teams. Treatment included systemic corticosteroids and hydroxychloroquine, along with supportive obstetric care. Despite conservative management, the patient developed signs of impending abortion and subsequently experienced a complete spontaneous abortion. Post-abortion care was provided, and the patient remained hemodynamically stable. This case highlights the significant impact of systemic lupus erythematosus on pregnancy outcomes, particularly recurrent pregnancy loss, even in patients with mild disease activity. Early diagnosis, preconception counseling, and close multidisciplinary monitoring throughout pregnancy are crucial to reduce maternal and fetal morbidity in women with SLE.
Co-Authors Rahmi Syukra Fadilla