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All Journal Indonesian Journal of Medicine Health and Medical Journal JURNAL ILMIAH SIMANTEK Nommensen Journal of Medicine Jurnal EduHealth
Lamtiar, Rebecca Rumesty
UNIVERSITAS HKBP NOMMENSEN
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Journal : Indonesian Journal of Medicine

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Comparison of Soluble fms-Like Tyrosine Kinase-1 (SFLT-1) between Normal and Severe Pre-eclampsia in Pregnant Women, Medan, Indonesia Lamtiar, Rebecca Rumesty; Mutiara, Erna; Raja, Sarma N Lumban
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The pathogenesis of pre-eclampsia as a primary cause of mortality among pregnant women remains unclear. It was suggested that angiogenic factors such as Soluble fms-Like Tyrosine Kinase-1 (SFLT-1) play an important role in the causal mechanism of pre-eclampsia/ eclampsia. This study aimed to compare the SFLT-1 level in pre-eclampsia/eclampsia in pregnant women with that in normotensive pregnant women.Subjects and Method: This was an analytic observational conducted at three hospitals: Haji Adam Malik, Pirngadi, and Sundari Hospitals, Medan, Indonesia, from September to December 2014. A total sample of 60 pregnant women of the third trimester, including those with severe pre-eclampsia/eclampsia and normotensive women, was selected for this study. The level of serum SFLT-1 was measured by ELISA method. The difference in mean of serum SFLT-1 levels between the two groups was tested by Mann-Whitney.Results: The mean of serum SFLT-1 level in women with preeclampsia was higher (mean=1692.69pg/ml; SD=540.64) than that in normotensive women (mean=1348.52pg/ml; SD=649.83). This difference was statistically significant (p=0.040).Conclusion: Level of serum SFLT-1 in women with severe pre-eclampsia/eclampsia is significantly higher than that of normotensive women.Keywords: serum SFLT-1, pre-eclampsia, pregnant womenCorrespondence: Rebecca Rumesty Lamtiar. Department of Physiology, Faculty of Medicine, HKBP Nommensen University, Medan.Indonesian Journal of Medicine (2016), 1(2): 84-89https://doi.org/10.26911/theijmed.2016.01.02.01
Co-Authors Amelia Saragih Erna Mutiara Fansisca Siallagan Raja, Sarma N Lumban Roderthani, Ita L Roy Abednego Purba Rumahorbo, Deby Berliana Saharnauli Janna Verawaty Simorangkir Sibarani, Erwin Piter Sisca Silvana VANNESSA ANGELICA