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All Journal Dekave : Jurnal Desain Komunikasi Visual Jurnal Kimia Riset
Dhani, Muhammad
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Arts Humanities Chemistry

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Molecular Docking Study of Bioactive Compounds in Senggugu (Clerodendrum serratum (L.) Moon) as Antidiabetics Rhahmadini, Yahdi Thia; Mulatsari, Esti; Taqwa, Iqbal Ananda; Dhani, Muhammad; Mawijaya, Agus; Susanti, Evi; Simanjuntak, Josua Donrio; Mumpuni, Esti; Prasetiyo, Andri
Jurnal Kimia Riset Vol. 10 No. 1 (2025): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v10i1.68455

Abstract

Senggugu has the potential to be a source of natural medicine through its compounds. Using in silico approaches is an effective strategy for exploring compounds from natural products in the screening process. In vivo studies on senggugu have indicated that the plant has antidiabetic activity, although the active compounds involved in this activity are unknown. This study aims to explore the content of bioactive compounds of Senggugu (Clerodendrum serratum (L.) Moon) and its mechanism of action as an antidiabetic in silico with Molegro Virtual Docker software, ChemDraw, visualization with Discovery Studio, and ADMET prediction with pkCSM. The study was conducted by simulating the molecular docking of 31 bioactive compounds in Senggugu (Clerodendrum serratum (L.) Moon) with comparison compounds using glibenclamide, miglitol, rosiglitazone, linagliptin, and empagliflozin. The validated target proteins comprised 5 (five) receptors with PDB ID codes 4YVP, 5NN6, 7AWC, 6Y0F, and 7VSI. Based on this study, the compound predicted to be active as an antidiabetic is [(1S,2S,6R,7S,11R)-11-hydroxy-5,9,13-trimethylidene-4-oxo-3,14-dioxatricyclo [9.2.1.02,6] tetradecan-7-yl]2-methylprop-2-enoate at receptor 4YVP with a rerank score of -107.663 kcal/mol with glibenclamide -94.8299 kcal/mol and [3-hydroxy-4-[(2R)-6-methylhept-5-en-2yl]phenyl]methyl3-methylbut-2-enoate at 5NN6 receptor with a rerank score of -87.8719 with miglitol -64.7212 kcal/mol.
Perancangan Dokumenter VR 360° sebagai Media Eksplorasi Petualangan Digital pada Situs Prasejarah Karst Sangkulirang-Mangkalihat Dhani, Muhammad; Rizky Mutiaz, Intan
DEKAVE : Jurnal Desain Komunikasi Visual Vol 15, No 3 (2025): inpress
Publisher : Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/dekave.v15i3.134791

Abstract

Kawasan Karst Sangkulirang-Mangkalihat di Kalimantan Timur menyimpan seni cadas figuratif berusia lebih dari 40 000 tahun menjadi salah satu situs prasejarah penting di Indonesia. Terdapat beragam hambatan mulai dari akses transportasi hingga alasan keamanan dan keselamatan untuk mengunjungi cagar budaya tersebut. Penelitian berfokus pada perancangan solusi pengalaman digital melalui dokumenter VR berbasis video 360°. Metode perancangan melalui tahapan pra-produksi, produksi, dan pascaproduksi mengadaptasi framework design thinking. Tahapan perancangan menghasilkan prototype 1 yang diujikan kepada 19 siswa dari jenjang SMA/SMK di SMKN 15 Samarinda, SMAN 8 Samarinda, SMAN 10 Samarinda. Hasil pengujian menunjukan berbasis Wilcoxon mengonfirmasi kenaikan skor pengetahuan rata-rata 4,05 poin (Z = −3,823; p < 0,001). Dimensi Kehadiran memperoleh skor tertinggi (M = 4,58/5), dan 89 % responden menilai sudut pandang orang pertama sebagai aspek paling imersif; 95. Berdasarkan hasil pengujian dilakukan iterasi hingga menghasilkan prototype 2 yang terdiri dari tiga episode dokumenter VR. Disitribusi karya akan dilakukan melalui microsite yang berperan sebagai sumber informasi dan ruang diskusi para penonton. Hasil penelitian menunjukan dokumenter VR efektif digunakan sebagai media pengenalan cagar budaya yang sulit diakses melalui pengalaman petualangan digital.
Co-Authors Andri Prasetiyo Esti Mumpuni, Esti Evi Susanti Mawijaya, Agus Mulatsari, Esti Rhahmadini, Yahdi Thia Rizky Mutiaz, Intan Simanjuntak, Josua Donrio Taqwa, Iqbal Ananda