Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Sciences of Phytochemistry
Olaiya, Akeem Ayodele
Unknown Affiliation
Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Phytochemical and Antiplasmodial Studies of Methanol Extract from Aerial Parts of Scadoxus multiflorus Olaiya, Akeem Ayodele; Tijani, Tawakaltu Omolara; Garba, Dauda; Abdullahi, Sakynah Musa; Sule, Ibrahim Mohammed
Sciences of Phytochemistry Volume 4 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0401309

Abstract

Scadoxus multiflorus, a fleshy herbaceous plant with a large bulb, has been traditionally used in ethnomedicine for treatment of malaria, ulcers, cardiotonic activity and stimulant in debility. This study aimed to conduct phytochemical screening and evaluate the antiplasmodial activity of its aerial parts. The plant material was extracted with methanol using maceration process, and the crude extract was partitioned into hexane, chloroform, ethyl acetate, and butanol fractions. Qualitative phytochemical screening revealed the presence of tannins, flavonoids, alkaloids, terpenoids, steroids, saponins, phenols, and cardiac glycosides in the crude extract and fractions. Quantitative analysis revealed that phenolic compounds were the most abundant in the crude extract (198.32 mg/g), while alkaloids were the least (51.14 mg/g). The n-hexane fraction, however, had the highest tannin content (215 mg/g). Acute toxicity testing, following OECD 2008 guidelines, showed that the median lethal dose (LD₅₀) was greater than 5000 mg/kg, indicating the extract's safety. Antiplasmodial activity was evaluated using both suppressive and curative models in Plasmodium berghei-infected albino mice. The extract at 1000 mg/kg significantly suppressed parasitemia by 58.8% in the early infection (suppressive test) and reduced parasitemia by 61.8% in the established infection (curative test). Chloroquine, the standard drug at 5 mg/kg, produced higher parasite suppression (84.52%) and curative effects (84.50%) compared to the extract. The results suggest that the methanol extract of S. multiflorus aerial parts possesses antiplasmodial activity, supporting its traditional use in malaria management.
Exploring the Anti-Malarial Potential of Terminalia brownii Fresen: A Phytochemical and Biological Activity Study Tijani, Tawakaltu Omolara; Olaiya, Akeem Ayodele; Garba, Dauda; Atiku, Ibrahim; Sule, Muhammed Ibrahim
Sciences of Phytochemistry Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0402328

Abstract

Terminalia brownii is a widely distributed African tree traditionally used to treat ailments such as cough, malaria, hepatitis, and microbial infections. The growing resistance of Plasmodium falciparum to Artemisinin combination therapy and other antimalarial drugs highlights the need for new therapies with improved potency and fewer side effects. This study analyzed the phytochemical constituents and antiplasmodial activity of T. brownii leaf extracts. The leaves were air-dried, powdered, and macerated in 70% methanol, followed by fractionation with n-hexane, chloroform, and ethyl acetate. Qualitative analysis of the methanol crude extract (MCE) revealed tannins, flavonoids, alkaloids, triterpenes, steroids, saponins, phenols, and cardiac glycosides, but not anthraquinones. Quantitative analysis showed phenols (195.45 mg/g), tannins (156.10 mg/g), and flavonoids (135.10 mg/g) as the most abundant. The ethyl acetate fraction contained phenols (103 mg/g) and tannins (69.56 mg/g) but lacked steroids and triterpenes. Antiplasmodial activity was evaluated in Plasmodium berghei-infected mice. The LD50 of the crude extract exceeded 5000 mg/kg, and significant dose-dependent suppression of parasitemia (p<0.05) was observed at 250, 500, and 1000 mg/kg. These findings support the traditional use of T. brownii against malaria and encourage further studies on its bioactive fractions and compounds.
Co-Authors Abdullahi, Sakynah Musa Atiku, Ibrahim Garba, Dauda Sule, Ibrahim Mohammed Sule, Muhammed Ibrahim Tijani, Tawakaltu Omolara