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Tahir, Albashir
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Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

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Analgesic and Anti-Inflammatory Effects of Ethanol Leaf Extract of Guiera Senegalensis in Murine Models Hassan, Umar Abdulkadir; Tahir, Jalilah Ibrahim; Akanji, Comfort Foluwake; Adamu, Abdulmutalib; Tahir, Albashir
Sciences of Phytochemistry Volume 4 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0401300

Abstract

Pain and inflammation are global public health challenges, often requiring safer and more effective treatments. Medicinal plants like Guiera senegalensis have been traditionally used for pain and inflammatory conditions, but scientific validation of their therapeutic potential is limited. This study aimed to evaluate the analgesic and anti-inflammatory properties of ethanol leaf extract of G. senegalensis in murine models. Fresh G. senegalensis leaves were collected, authenticated, and subjected to ethanol extraction. Phytochemical analysis was conducted to identify bioactive compounds. Acute toxicity studies were performed following OECD guidelines. Analgesic effects were evaluated using the acetic acid-induced writhing test and the hot plate test, while the anti-inflammatory activity was assessed using the formalin-induced paw edema model. Phytochemical analysis revealed the presence of tannins, saponins, and flavonoids. Acute toxicity tests showed no mortality or severe adverse effects at 2000 mg/kg. The extract demonstrated dose-dependent analgesic activity, with 84% inhibition of writhing at doses of 25 mg/kg and 50 mg/kg, outperforming Diclofenac (59%). In the hot plate test, moderate central analgesic effects were observed. Anti-inflammatory tests showed significant reductions in paw edema at doses of 12.5 and 25 mg/kg, comparable to Diclofenac. Ethanol leaf extract of G. senegalensis exhibits significant analgesic and anti-inflammatory activities, likely mediated by its flavonoid, saponin, and tannin content. These findings support its traditional use and highlight its potential as a natural alternative for managing pain and inflammation.
Boswellia dalzielii Methanol Stem Bark Extract Demonstrates Significant Analgesic Activity in Swiss Albino Mice Abubakar, Hauwau; Tahir, Albashir; Umar, Aminu Kura
Sciences of Phytochemistry Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0301225

Abstract

Medicinal plants are gaining popularity as safer and more natural alternatives to orthodox medicines for managing health challenges and diseases. One such plant is Boswellia dalzielii, a renowned tree in northern Nigeria extensively used due to its ethnomedicinal importance. To determine the analgesic properties of Boswellia dalzielii methanol extract (BDME), the extract was screened in mice using thermal and acetic acid-induced pain models. The extract's acute toxicity and phytochemical constituents were determined using standard protocols. The results showed that the acute toxicity of the methanol stem bark extract was greater than 2000 mg/kg. Phytochemical screening of BDME revealed the presence of flavonoids, tannins, saponins, and glycosides. The extract, at the dose of 50 mg/kg significantly (p < 0.05) prolonged the pain reaction time at 15 and 30 minutes in the hot plate test, and reduced acetic acid-induced writhing at the 12.5, 25, and 50 mg/kg doses. The analgesic activity of the extract may be attributed to the phytochemical contents. The findings suggest that BDME have analgesic properties and could be beneficial in alleviating painful conditions.
Phytochemical and Behavioral Assessment of Guiera senegalensis for Antidepressant Activity Muazu, Ibrahim Khaleel; Nasir, Aisha Balanmalam; Tahir, Albashir
Sciences of Phytochemistry Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0402416

Abstract

Depression is a prevalent and debilitating mental disorder that significantly affects global health and quality of life. Conventional pharmacological treatments have adverse effects, necessitating the search for alternative therapies. This study aimed to evaluate the potential antidepressant activity of the ethanol leaf extract of Guiera senegalensis in Wistar rats. Phytochemical screening was performed to identify bioactive compounds in the extract. Acute toxicity was assessed following OECD guidelines, with doses up to 5000 mg/kg. The antidepressant activity was evaluated using the Forced Swim Test (FST) and Tail Suspension Test (TST). Experimental groups received extract doses of 25, 50, and 100 mg/kg, with control groups receiving normal saline and reference groups treated with imipramine (10 mg/kg). Statistical analyses were conducted using one-way ANOVA with Dunnett’s post hoc test. Phytochemical analysis revealed the presence of flavonoids, tannins, and saponins, which are known for their neuropharmacological properties. Acute toxicity testing showed no mortality at 5000 mg/kg, indicating a high safety profile. Behavioral assessments demonstrated that the extract significantly reduced immobility time in the FST and TST at doses of 50 and 100 mg/kg (p < 0.05), suggesting antidepressant activity. The ethanol leaf extract of G. senegalensis exhibits both antidepressant effects in animal models, supporting its traditional use in managing mood disorders. The presence of bioactive compounds suggests a pharmacological basis for its efficacy. Further research is needed to elucidate its mechanisms of action and assess its long-term safety.
Co-Authors Abubakar, Hauwau Adamu, Abdulmutalib Akanji, Comfort Foluwake Hassan, Umar Abdulkadir Muazu, Ibrahim Khaleel Nasir, Aisha Balanmalam Tahir, Jalilah Ibrahim Umar, Aminu Kura