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Harlita Harlita
Sebelas Maret University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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The Effect of Cucumber (Cucumis Sativus) Feeding on the Estrus Cycle in Female Mice (Mus musculus) Fassa Atif Aprilia; Harlita Harlita
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.331-336

Abstract

Cucumbers (Cucumis sativus) are plants that contain bioactive compounds such as flavonoids and phytoestrogens that resemble the hormone estrogen, so they have the potential to affect the reproductive system. One of the indicators of the balance of reproductive hormones in female animals is the etrus cycle. An imbalance of the hormones estrogen and progesterone can cause changes in the duration of the etruscan cycle. This study aims to determine the effect of cucumber extract administration on the estrus cycle of female rats (Mus musculus). This study is an experimental study with Complete Random Design (CRD). A total of 9 female rats were divided into three groups, namely the control group, the treatment group with a dose of 200 mg/kg body weight, and the treatment group with a dose of 300 mg/kg body weight. Cucumber extract is administered orally for 15 days. Observation of the estrus cycle is carried out daily by the vaginal swab method. The data were analyzed using a one-way analysis of variance test. The results showed that the average duration of the estrus cycle of the control group was 4.8 days, the 200 mg/kg BB dose treatment group was 6.1 days, and the 300 mg/kg BB dose treatment group was 4.6 days. The results of statistical analysis showed that the administration of cucumber extract did not have a significant effect on the estrus cycle of female mice (p > 0.05). It can be concluded that administration of cucumber extract at doses of 200 mg/kg BB and 300 mg/kg BB did not have a significant effect on the estrus cycle of female rats, although there is a tendency to alter the length of the estrus phase in some individuals.
Effect of Ethanol Extract of Cherry (Muntingia calabura L.) Leaves on the Estrous Cycle in Female Mice (Mus musculus) Maulidatuz Zahro; Harlita Harlita
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.313-317

Abstract

Cherry (Muntingia calabura L.) leaves contain primary secondary metabolites in the form of flavonoids that have the potential to inhibit fertility by interfering with ovarian, uterus, or vaginal function. One of the parameters that can be used to assess the antifertility potential of a compound or herbal extract is the estrous cycle. This study aimed to determine the effect of cherry leaves ethanol extract intake on the estrous cycle in female mice (Mus musculus). This study used a Complete Random Design (CRD) with 3 treatments, namely control of Na CMC 1% (C), cherry leaves extract at a dose of 125 mg/kg of mice body weight (T1), and 250 mg/kg of mice body weight (T2), each with 3 replicates. The results showed that cherry leaves ethanol extract did not have a significant effect on the length of the estrous cycle of mice analyzed by the Kruskal–Wallis test (Asymp value. Sig > 0.05), although there is a tendency for the estrous cycle in the treatment group to be longer than the control group. This study provides insights for follow-up research with more diverse doses, treatment duration, and reproductive parameters in determining the antifertility activity of an herbal metabolite compound.
Co-Authors Fassa Atif Aprilia Maulidatuz Zahro