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All Journal The Avicenna Medical Journal Barongko : Jurnal Ilmu Kesehatan
Ridwan, Muhammad Rafif
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Biochemistry, Genetics & Molecular Biology Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Peran Status Zat Besi Dan Gizi Makro-Mikro Sebagai Determinan Risiko Infeksi Cacing Usus (STH) Pada Anak Di Daerah Endemis Hidana, Rachma; Nababan, Diana Listy L.P.; Ridwan, Muhammad Rafif; Sidik, Ahmad Fajar; Pertiwi, Intan Putri; M, Nur Khalisha Yahya; Subkhi, M. Umar; Marcellino, Mario; Cesia, Maria Kasih; Naziihah, Naura Adhwa; Fajri, Andi Muhammad; Apsari, Shafira Nova
Barongko: Jurnal Ilmu Kesehatan Vol. 3 No. 3 (2025): Barongko : Jurnal Ilmu Kesehatan (Juli)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/bajik.v3i3.739

Abstract

Soil-Transmitted Helminths (STH) remain a significant public health problem in endemic areas, especially among children. STH infections contribute to decreased nutritional status, iron deficiency anemia, and growth and cognitive disorders. This literature review aims to analyze the relationship between iron status, macro- and micronutrient intake, and the risk of STH infection in children. Articles were searched through Google Scholar, PubMed, ScienceDirect, and Web of Science with inclusion criteria covering publications from 2015–2025, observational studies on children under 18 years old, and discussions on the link between nutritional status and STH. The results show that STH infections cause anemia through intestinal bleeding, malabsorption, and chronic inflammation that increases hepcidin levels. Deficiencies in protein, energy, iron, zinc, and vitamin A can weaken immunity and worsen the cycle of malnutrition. Relying solely on mass deworming programs is insufficient without improvements in sanitation, nutrition education, and supplementation of essential nutrients. It is expected that this review can serve as a basis for holistic intervention recommendations to reduce the prevalence of STH infections among children in endemic areas.
Comparison of the Effectiveness of Ringer’s Lactate and 0.9% NaCl on Mortality in Adult Sepsis Patients: An Evidence-Based Case Report Ridwan, Muhammad Rafif; Ridwan, Faras Khairunnisa; Ridwan, Muhammad Ijlal; Surianty Susilo
The Avicenna Medical Journal Vol. 6 No. 2 (2025): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v6i2.47192

Abstract

Background: The selection of crystalloid fluid in sepsis resuscitation affects acid-base balance, organ perfusion, and mortality. 0.9% NaCl (normal saline, NS) is the standard fluid, but its high chloride content has the potential to cause physiological disturbances. In contrast, balanced crystalloids such as Ringer's Lactate (RL) have an electrolyte composition closer to physiological plasma and are thought to provide better clinical outcomes. Recent evidence suggests a possible role for RL in reducing mortality in patients with sepsis, although some studies report mixed results. This study aims to evaluate the effectiveness of Ringer's Lactate compared to 0.9% NaCl on mortality in adult patients with sepsis, using an evidence-based case report approach to inform fluid resuscitation decisions. Methods: A literature search was conducted in October 2025 through PubMed NCBI, Medline EBSCO, ScienceDirect, and Google Scholar. Four studies met the inclusion criteria (3 RCTs, 1 SR/MA of RCTs) and were subsequently screened according to the Centre for Evidence-Based Medicine (CEBM) guidelines for critical appraisal, relative to validity, relevance, and practicality to the clinical scenario. Results: Across the included studies, the direction of effect generally favored RL over NS with respect to mortality outcomes. However, effect estimates were reported using different measures, including risk ratios and hazard ratios, and not all observed differences reached statistical significance. Given methodological heterogeneity and identified risks of bias, quantitative pooling of results was not performed, and findings were interpreted qualitatively. Conclusion: The use of Ringer’s Lactate in adult patients with sepsis appears to be associated with a favorable direction of effect on mortality compared with 0.9 NaCl. Nevertheless, the certainty of this evidence is limited, and definitive conclusions regarding superiority cannot be drawn. Keywords: NaCl, balanced crystalloid, normal saline, mortality, Ringer’s lactate, sepsis
Co-Authors Apsari, Shafira Nova Cesia, Maria Kasih Fajri, Andi Muhammad Hidana, Rachma M, Nur Khalisha Yahya Marcellino, Mario Nababan, Diana Listy L.P. Naziihah, Naura Adhwa Pertiwi, Intan Putri Ridwan, Faras Khairunnisa Ridwan, Muhammad Ijlal Sidik, Ahmad Fajar Subkhi, M. Umar Surianty Susilo