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All Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Hussam Z.Naji
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Health Professions Nursing Public Health

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Synthesis and Estimate of Antimicrobial Efficacy of New Benzoic Acid Hydrazide Derivatives Substituted by Piperidine Hussam Z.Naji; Ghosoun Lafta Mohsen
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1532

Abstract

Several of the best-selling small-molecule medications and natural alkaloids contain piperidine, a crucial saturated heterocyclic scaffold with a wide variety of biological functions. The hydrazide-hydrazone moiety's exceptional use in the pharmacological and biological domains made it particularly appealing. Objective: Designing and synthesizing a novel set of 4-Piperidin-1-yl-benzoic acid substituted hydrazides, Ac1-c3 and Bc1-c5, as potentially antimicrobial agents and characterizing them using IR, 1H-NMR, and mass spectroscopy. Methods: By esterifying 4- Piperidin-1-yl-benzoic acid Ac1 and then treating with hydrazine hydrate it to produce Ac3 in a good yield. The hydrazide Ac3 was condensed with the proper aldehydes or ketone to synthesis the hydrazones Bc1–c5. The in vitro bacterial activity was evaluated anti two Gram-negative bacteria, Pseudomonas aeruginosa, and Candida albicans, as well as two Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis. Results: The majority of tested compounds demonstrated significant efficacy anti Pseudomonas aeruginosa, Candida albicans. Notably, compound Bc3 emerged as the most effective derivative within the series. Conclusions: The Compounds (Bc1–c4) that were synthesized demonstrated moderate to good antimicrobial activity against a number of bacterias species and Candida albicans.
Co-Authors Ghosoun Lafta Mohsen