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All Journal Journal of Clinical Microbiology and Infectious Diseases
Rahayu, Siwipeni I.
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Immunology & microbiology

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The effect of prolonged exposure to the antibiotic meropenem on the resistance characteristics of Acinetobacter baumannii in vitro Sutjipto, Yossy I.; Rahayu, Siwipeni I.; Santosaningsih, Dewi
Journal of Clinical Microbiology and Infectious Diseases Vol. 5 No. 1 (2025): Available online : 1 June 2025
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v5i1.71

Abstract

Introduction: To prove the effect of prolonged exposure to the antibiotic meropenem on the emergence of Acinetobacter baumannii resistance in vitro. Methods: Meropenem-susceptible Acinetobacter baumannii isolates were exposed to 0.1 mg/ml meropenem and incubated for 8 days. The optical density and number of Acinetobacter baumannii bacterial colonies were observed every 24 hours. The average of optical density and the number of Acinetobacter baumannii bacterial colonies growing every 24 hours were analyzed using the Kruskal-Wallis test. Results: The results showed a decrease in the average optical density value and the number of Acinetobacter baumannii bacterial colonies from day 1 to day 6 of incubation. However, there was an increase in the average optical density and the number of Acinetobacter baumannii bacterial colonies starting on day 7 and day 8. Conclusions: Exposure to the antibiotic meropenem 0.1 mg/ml for 6 days might be associated with the emergence of Acinetobacter baumannii resistance in vitro.
Co-Authors Dewi Santosaningsih Sutjipto, Yossy I.